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cpeb4a cytoplasmic polyadenylation element binding protein 4a [ Danio rerio (zebrafish) ]

Gene ID: 393956, updated on 4-Jan-2025

Summary

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Official Symbol
cpeb4aprovided by ZNC
Official Full Name
cytoplasmic polyadenylation element binding protein 4aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1557
See related
Ensembl:ENSDARG00000056691 AllianceGenome:ZFIN:ZDB-GENE-040426-1557
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Cpeb3; cpeb4; zgc:66166
Summary
Predicted to enable mRNA 3'-UTR binding activity; ribosome binding activity; and translation regulator activity, nucleic acid binding. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of cytoplasmic translation; and response to ischemia. Predicted to act upstream of or within regulation of translation. Predicted to be located in dendrite; endoplasmic reticulum; and postsynaptic density. Predicted to be active in several cellular components, including neuron projection; nucleus; and synapse. Is expressed in cranial ganglion; neurons; olfactory placode; peripheral olfactory organ; and yolk syncytial layer. Orthologous to human CPEB4 (cytoplasmic polyadenylation element binding protein 4). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See cpeb4a in Genome Data Viewer
Location:
chromosome: 14
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (24096588..24110736, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (23794373..23813519, complement)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:ch211-277c7.7 Neighboring gene muscle segment homeobox 2a Neighboring gene stanniocalcin 2a Neighboring gene NK2 homeobox 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC66166

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA regulatory element binding translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to amino acid stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to decreased oxygen levels ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in ionotropic glutamate receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ischemia ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in growth cone IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytoplasmic polyadenylation element-binding protein 4
Names
CPE-binding protein 4
cytoplasmatic polyadenylation element binding protein 4
cytoplasmic polyadenylation element binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001351720.1 → NP_001338649.1  cytoplasmic polyadenylation element-binding protein 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL935195, EH486763, EH535381
    UniProtKB/Swiss-Prot
    Q7SXN4
    UniProtKB/TrEMBL
    A0A286YBB6, A0A8M1P9S4, B2GRL1, F1QCY1
    Related
    ENSDARP00000109818.1, ENSDART00000123152.3
    Conserved Domains (3) summary
    cd12724
    Location:446 → 537
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:554 → 634
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:629 → 690
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

  2. NM_200981.2 → NP_957275.2  cytoplasmic polyadenylation element-binding protein 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL935195, EH535381
    UniProtKB/Swiss-Prot
    Q7SXN4
    UniProtKB/TrEMBL
    A0A286YBB6, A0A8M1P9S4, B2GRL1, F1QCY1
    Related
    ENSDARP00000073682.4, ENSDART00000079226.6
    Conserved Domains (3) summary
    cd12724
    Location:446 → 537
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:554 → 634
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:629 → 690
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    24096588..24110736 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005173113.5 → XP_005173170.2  cytoplasmic polyadenylation element-binding protein 4 isoform X1

    See identical proteins and their annotated locations for XP_005173170.2

    UniProtKB/Swiss-Prot
    Q7SXN4
    UniProtKB/TrEMBL
    A0A2R8RYC4, A0A8M3AHT9, B2GRL1
    Related
    ENSDARP00000155912.1, ENSDART00000186611.1
    Conserved Domains (4) summary
    COG0724
    Location:333 → 616
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:454 → 545
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:562 → 642
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:637 → 698
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

  2. XM_009291021.4 → XP_009289296.1  cytoplasmic polyadenylation element-binding protein 4 isoform X1

    See identical proteins and their annotated locations for XP_009289296.1

    UniProtKB/Swiss-Prot
    Q7SXN4
    UniProtKB/TrEMBL
    A0A2R8RYC4, A0A8M3AHT9, B2GRL1
    Conserved Domains (4) summary
    COG0724
    Location:333 → 616
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:454 → 545
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:562 → 642
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:637 → 698
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394909.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    65676..79824 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7SXN4.1 GenPept UniProtKB/Swiss-Prot:Q7SXN4

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