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pds5a PDS5 cohesin associated factor A [ Danio rerio (zebrafish) ]

Gene ID: 393967, updated on 4-Jan-2025

Summary

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Official Symbol
pds5aprovided by ZNC
Official Full Name
PDS5 cohesin associated factor Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1612
See related
Ensembl:ENSDARG00000055022 AllianceGenome:ZFIN:ZDB-GENE-040426-1612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Aprin; zgc:66331; zgc:153878
Summary
Predicted to be involved in DNA repair; mitotic sister chromatid cohesion; and negative regulation of DNA replication. Predicted to act upstream of or within cell division. Predicted to be located in chromatin. Predicted to be active in nucleus. Orthologous to human PDS5A (PDS5 cohesin associated factor A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See pds5a in Genome Data Viewer
Location:
chromosome: 1
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (23323287..23370529, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (22632559..22679820, complement)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene small integral membrane protein 14 Neighboring gene ubiquitin-conjugating enzyme E2Kb (UBC1 homolog, yeast) Neighboring gene NEDD4 binding protein 2 Neighboring gene ras homolog family member H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Expression of cohesin and condensin genes during zebrafish development supports a non-proliferative role for cohesin. Mönnich M, et al. Gene Expr Patterns, 2009 Dec. PMID 19723591
  2. High-throughput genome editing and phenotyping facilitated by high resolution melting curve analysis. Thomas HR, et al. PLoS One, 2014. PMID 25503746, Free PMC Article
  3. Knockdown screening of chromatin binding and regulatory proteins in zebrafish identified Suz12b as a regulator of tfpia and an antithrombotic drug target. Raman R, et al. Sci Rep, 2021 Jul 27. PMID 34315984, Free PMC Article
  4. Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Zeng S, et al. Gene, 2002 Jul 10. PMID 12234666
  5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC66331, MGC153878

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA replication ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sister chromatid cohesion protein PDS5 homolog A
Names
PDS5, regulator of cohesion maintenance, homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200992.3 → NP_957286.3  sister chromatid cohesion protein PDS5 homolog A

    Status: VALIDATED

    Source sequence(s)
    CR759875
    UniProtKB/Swiss-Prot
    A1L1F4
    UniProtKB/TrEMBL
    A0A8M2BI71, F1QDE7
    Related
    ENSDARP00000109877.2, ENSDART00000126785.4

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    23323287..23370529 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005170916.5 → XP_005170973.1  sister chromatid cohesion protein PDS5 homolog A isoform X2

    UniProtKB/Swiss-Prot
    A1L1F4
    UniProtKB/TrEMBL
    A0A8M2BI71, F1QDE7
    Conserved Domains (2) summary
    pfam06614
    Location:1221 → 1318
    Neuromodulin; Neuromodulin
    sd00044
    Location:279 → 309
    HEAT; HEAT repeat [structural motif]

  2. XM_068214592.1 → XP_068070693.1  sister chromatid cohesion protein PDS5 homolog A isoform X1

    UniProtKB/Swiss-Prot
    A1L1F4

  3. XM_068214606.1 → XP_068070707.1  sister chromatid cohesion protein PDS5 homolog A isoform X1

    UniProtKB/Swiss-Prot
    A1L1F4

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394481.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    58757..105993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A1L1F4.1 GenPept UniProtKB/Swiss-Prot:A1L1F4

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