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Cep135 Centrosomal protein 135kDa [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39647, updated on 2-Nov-2024

Summary

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Official Symbol
Cep135provided by FlyBase
Official Full Name
Centrosomal protein 135kDaprovided by FlyBase
Primary source
FLYBASE:FBgn0036480
Locus tag
Dmel_CG17081
See related
AllianceGenome:FB:FBgn0036480
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Bld-10; bld10; Bld10; BLD10; Bld10p; CEP135; Cep135/bld10; CG17081; dbld10; DBld10; DCep135; DCep135/Bld10; DmBLD10; Dmel\CG17081
Summary
Enables microtubule binding activity. Involved in several processes, including microtubule cytoskeleton organization; negative regulation of microtubule depolymerization; and non-motile cilium assembly. Located in ciliary transition zone and microtubule organizing center. Is expressed in embryonic brain; larval ventral nerve cord; organism; and spermatozoon. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 8 and spermatogenic failure 26. Orthologous to several human genes including CEP135 (centrosomal protein 135). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Cep135 in Genome Data Viewer
Location:
71B5-71B5; 3-42 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15116737..15128029)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15109837..15121129)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene CTP synthase Neighboring gene antisense RNA:CR43971 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU5-U42 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45396 Neighboring gene Protein disulfide isomerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. BLD10/CEP135 is a microtubule-associated protein that controls the formation of the flagellum central microtubule pair. Carvalho-Santos Z, et al. Dev Cell, 2012 Aug 14. PMID 22898782
  2. Conserved molecular interactions in centriole-to-centrosome conversion. Fu J, et al. Nat Cell Biol, 2016 Jan. PMID 26595382, Free PMC Article
  3. Drosophila Ana1 is required for centrosome assembly and centriole elongation. Saurya S, et al. J Cell Sci, 2016 Jul 1. PMID 27206860, Free PMC Article
  4. Comprehensive review on the molecular genetics of autosomal recessive primary microcephaly (MCPH). Naveed M, et al. Genet Res (Camb), 2018 Aug 8. PMID 30086807, Free PMC Article
  5. Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation. Roque H, et al. J Cell Sci, 2012 Dec 1. PMID 22976301

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ana1 mutants lack detectable centrosomes in vivo, that Ana1 is irreversibly incorporated into centrioles during their assembly and appears to play a more important role in maintaining Asl at centrioles than in initially recruiting Asl to centrioles...the N-terminal region of Ana1 (amino acids 1-935) is required to target Ana1 to centrioles through a direct interaction with Cep135, whereas the C-terminal region of Ana1.
    Title: Drosophila Ana1 is required for centrosome assembly and centriole elongation.
  2. The centriolar protein Bld10/Cep135 is required to establish centrosome asymmetry in Drosophila neuroblasts.
    Title: The centriolar protein Bld10/Cep135 is required to establish centrosome asymmetry in Drosophila neuroblasts.
  3. Cep135/Bld10 is not essential for cartwheel assembly or for establishing the ninefold symmetry of centrioles; rather, it appears to stabilize the connection between inner and outer centriole components.
    Title: Drosophila Cep135/Bld10 maintains proper centriole structure but is dispensable for cartwheel formation.
  4. work describes a genetically tractable system to study motile cilia formation and provides an explanation for BLD10/CEP135's role in assembling highly stable microtubule-based structures
    Title: BLD10/CEP135 is a microtubule-associated protein that controls the formation of the flagellum central microtubule pair.
  5. Drosophila Bld10 is required for centriole and axoneme assembly to confer cilium motility.
    Title: Drosophila bld10 is a centriolar protein that regulates centriole, basal body, and motile cilium assembly.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in asymmetric neuroblast division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centriole replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ciliary basal body organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic centrosome separation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
centrosomal protein 135kDa
Names
CG17081-PA
CG17081-PB
CG17081-PC
Cep135-PA
Cep135-PB
Cep135-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    15116737..15128029
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202179.2 → NP_001189108.1  centrosomal protein 135kDa, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189108.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MSL4
    Conserved Domains (2) summary
    COG1196
    Location:203 → 963
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19219
    Location:302 → 421
    DUF342; Protein of unknown function (DUF342)

  2. NM_001274940.1 → NP_001261869.1  centrosomal protein 135kDa, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCK8
    Conserved Domains (2) summary
    COG1196
    Location:203 → 945
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19219
    Location:302 → 421
    DUF342; Protein of unknown function (DUF342)

  3. NM_140492.4 → NP_648749.3  centrosomal protein 135kDa, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648749.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960T6, Q9VUL3
    Related
    FBpp0075391
    Conserved Domains (2) summary
    COG1196
    Location:203 → 957
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl19219
    Location:302 → 421
    DUF342; Protein of unknown function (DUF342)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MSL4 M9MSL4
M9PCK8 M9PCK8
Q960T6 Q960T6

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