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PTGS1 prostaglandin-endoperoxide synthase 1 [ Sus scrofa (pig) ]

Gene ID: 397541, updated on 17-Aug-2024

Summary

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Official Symbol
PTGS1provided by VGNC
Official Full Name
prostaglandin-endoperoxide synthase 1provided by VGNC
Primary source
VGNC:VGNC:91958
See related
Ensembl:ENSSSCG00000005533
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as
COX-1; PGHS-1
Expression
Broad expression in spleen (RPKM 37.2), lung (RPKM 32.3) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
11
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 1 NC_010443.5 (262456106..262482159)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 1 NC_010443.4 (294753789..294779835)

Chromosome 1 - NC_010443.5Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 18 Neighboring gene mitochondrial ribosome recycling factor Neighboring gene uncharacterized LOC106507054 Neighboring gene olfactory receptor 1L1-like Neighboring gene olfactory receptor 1L8-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
  • Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
  • BioProject: PRJNA311523
  • Publication: PMID 27646534
  • Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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Related articles in PubMed

  1. Brain death increases COX-1 and COX-2 expression in the renal medulla in a pig model. Hvas CL, et al. Acta Anaesthesiol Scand, 2014 Feb. PMID 24320706
  2. Expression of porcine endometrial prostaglandin synthase during the estrous cycle and early pregnancy, and following endocrine disruption of pregnancy. Ashworth MD, et al. Biol Reprod, 2006 Jun. PMID 16452463
  3. PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries. Uenishi H, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681463, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Brain death increases the expression of COX-1 and COX-2 mRNA in the renal medulla
    Title: Brain death increases COX-1 and COX-2 expression in the renal medulla in a pig model.
  2. Endometrial prostaglandin-endoperoxide synthase 1 (PTGS1) mRNA expression increased 2- to 3-fold after Day 10 of the estrous cycle and pregnancy, whereas PTGS2 mRNA expression increased 76-fold between Days 5 and 15 of the estrous cycle and pregnancy.
    Title: Expression of porcine endometrial prostaglandin synthase during the estrous cycle and early pregnancy, and following endocrine disruption of pregnancy.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables prostaglandin-endoperoxide synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cyclooxygenase pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
prostaglandin G/H synthase 1
Names
cyclooxygenase-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010443.5 Reference Sscrofa11.1 Primary Assembly

    Range
    262456106..262482159
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001926129.6 → XP_001926164.2  prostaglandin G/H synthase 1

    UniProtKB/TrEMBL
    A0A287ANF9, A0A8D0KC91, A0A8D0UI34
    Related
    ENSSSCP00000045461.1, ENSSSCT00000053729.2
    Conserved Domains (2) summary
    cd09816
    Location:90 → 576
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:33 → 70
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
Nucleotide Protein Strain
Heading Accession and Version

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