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Mo25 Mo25 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39858, updated on 4-Jan-2025

Summary

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Official Symbol
Mo25provided by FlyBase
Official Full Name
Mo25provided by FlyBase
Primary source
FLYBASE:FBgn0017572
Locus tag
Dmel_CG4083
See related
AllianceGenome:FB:FBgn0017572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4083; Dmel\CG4083; DmMo25; dMo25; Dmo25; l(3)00274; mo25
Summary
Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in intracellular signal transduction. Located in cytoplasm and nucleus. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval midgut; and embryonic/larval midgut primordium. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human CAB39 (calcium binding protein 39) and CAB39L (calcium binding protein 39 like). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

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See Mo25 in Genome Data Viewer
Location:
73B1-73B1; 3-44 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (16613218..16615472, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (16606318..16608572, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45865 Neighboring gene Suppressor of ref(2)P sterility Neighboring gene uncharacterized protein Neighboring gene Abl tyrosine kinase Neighboring gene baldspot Neighboring gene small nuclear RNA U12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular characterization of the Drosophila Mo25 gene, which is conserved among Drosophila, mouse, and yeast. Nozaki M, et al. DNA Cell Biol, 1996 Jun. PMID 8672247
  2. Intracellular Chloride and Scaffold Protein Mo25 Cooperatively Regulate Transepithelial Ion Transport through WNK Signaling in the Malpighian Tubule. Sun Q, et al. J Am Soc Nephrol, 2018 May. PMID 29602832, Free PMC Article
  3. Phosphorylation of LKB1 by PDK1 Inhibits Cell Proliferation and Organ Growth by Decreased Activation of AMPK. Borkowsky S, et al. Cells, 2023 Mar 6. PMID 36899949, Free PMC Article
  4. The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions. Yamamoto Y, et al. Biochem Biophys Res Commun, 2008 Feb 1. PMID 18054329
  5. Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression. Dogliotti G, et al. Nat Commun, 2017 Jun 26. PMID 28649994, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Mo25
Names
CG4083-PA
CG4083-PB
Mo25-PA
Mo25-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    16613218..16615472 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079393.2 → NP_524117.1  Mo25, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524117.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91891, Q540S2, Q9VV85
    UniProtKB/TrEMBL
    M9PI82
    Related
    FBpp0075117, FBtr0075358
    Conserved Domains (1) summary
    pfam08569
    Location:3 → 334
    Mo25; Mo25-like

  2. NM_001275029.1 → NP_001261958.1  Mo25, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261958.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P91891, Q540S2, Q9VV85
    UniProtKB/TrEMBL
    M9PI82
    Conserved Domains (1) summary
    pfam08569
    Location:3 → 334
    Mo25; Mo25-like
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PI82 M9PI82
P91891.2 P91891

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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