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CCDC187 coiled-coil domain containing 187 [ Homo sapiens (human) ]

Gene ID: 399693, updated on 27-Nov-2024

Summary

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Official Symbol
CCDC187provided by HGNC
Official Full Name
coiled-coil domain containing 187provided by HGNC
Primary source
HGNC:HGNC:30942
See related
Ensembl:ENSG00000260220 AllianceGenome:HGNC:30942
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in microtubule anchoring. Predicted to be located in centrosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 6.0), thyroid (RPKM 0.9) and 1 other tissue See more
Orthologs
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Genomic context

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See CCDC187 in Genome Data Viewer
Location:
9q34.3
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (136249973..136306901, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (148479614..148536390, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139141819..139166855, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139089541-139090232 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139090233-139090922 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139100281-139100832 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139100833-139101382 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139103280-139104056 Neighboring gene LIM homeobox 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139107853-139108356 Neighboring gene quiescin sulfhydryl oxidase 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29300 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29301 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29302 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:139119971-139121170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139131059-139131587 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20502 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20503 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139139693-139140547 Neighboring gene 9q34.3 QSOX2 distal recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20505 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:139159307-139159682 Neighboring gene uncharacterized LOC124902308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20506 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29304 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20507 Neighboring gene uncharacterized LOC26102 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139218370-139218998 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139218999-139219627 Neighboring gene Sharpr-MPRA regulatory region 1004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139222157-139222686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139222687-139223215 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139227274-139227906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139237289-139238070 Neighboring gene G protein signaling modulator 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139238071-139238852 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139239387-139240040 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139240041-139240694 Neighboring gene Sharpr-MPRA regulatory region 3186 Neighboring gene DNL-type zinc finger

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Quantitative gene profiling of long noncoding RNAs with targeted RNA sequencing. Clark MB, et al. Nat Methods, 2015 Apr. PMID 25751143
  2. FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia. Zhu XN, et al. J Hematol Oncol, 2023 Feb 11. PMID 36774506, Free PMC Article
  3. Assessment of community efforts to advance network-based prediction of protein-protein interactions. Wang XW, et al. Nat Commun, 2023 Mar 22. PMID 36949045, Free PMC Article
  4. Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms. Bagci H, et al. Nat Cell Biol, 2020 Jan. PMID 31871319
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC50722

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule anchoring IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coiled-coil domain-containing protein 187

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291516.1 → NP_001278445.1  coiled-coil domain-containing protein 187 isoform 1

    Status: VALIDATED

    Source sequence(s)
    FP326719
    Consensus CDS
    CCDS78462.1
    UniProtKB/Swiss-Prot
    A0A096LP49, Q8N5P7
    Related
    ENSP00000456543.1, ENST00000569961.5

  2. NM_001378188.1 → NP_001365117.1  coiled-coil domain-containing protein 187 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR392000, FP326719
    Consensus CDS
    CCDS94533.1
    UniProtKB/TrEMBL
    A0A1W2PQX5
    Related
    ENSP00000492326.1, ENST00000638797.2
    Conserved Domains (3) summary
    PHA03247
    Location:1348 → 1948
    PHA03247; large tegument protein UL36; Provisional
    PRK07764
    Location:1316 → 1526
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    NF033201
    Location:1234 → 1379
    Vip_LPXTG_Lm; cell invasion LPXTG protein Vip

RNA

  1. NR_111982.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    FP326719
    Related
    ENST00000563590.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    136249973..136306901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423386.1 → XP_047279342.1  coiled-coil domain-containing protein 187 isoform X10

  2. XM_047423384.1 → XP_047279340.1  coiled-coil domain-containing protein 187 isoform X8

  3. XM_047423385.1 → XP_047279341.1  coiled-coil domain-containing protein 187 isoform X9

  4. XM_047423383.1 → XP_047279339.1  coiled-coil domain-containing protein 187 isoform X7

  5. XM_047423382.1 → XP_047279338.1  coiled-coil domain-containing protein 187 isoform X6

  6. XM_047423380.1 → XP_047279336.1  coiled-coil domain-containing protein 187 isoform X4

  7. XM_047423381.1 → XP_047279337.1  coiled-coil domain-containing protein 187 isoform X5

  8. XM_047423379.1 → XP_047279335.1  coiled-coil domain-containing protein 187 isoform X3

  9. XM_047423388.1 → XP_047279344.1  coiled-coil domain-containing protein 187 isoform X12

  10. XM_047423387.1 → XP_047279343.1  coiled-coil domain-containing protein 187 isoform X11

  11. XM_047423378.1 → XP_047279334.1  coiled-coil domain-containing protein 187 isoform X2

  12. XM_047423377.1 → XP_047279333.1  coiled-coil domain-containing protein 187 isoform X1

  13. XM_047423389.1 → XP_047279345.1  coiled-coil domain-containing protein 187 isoform X13

  14. XM_011518681.3 → XP_011516983.1  coiled-coil domain-containing protein 187 isoform X14

    UniProtKB/Swiss-Prot
    A0A096LP49, Q8N5P7

RNA

  1. XR_007061299.1 RNA Sequence

  2. XR_007061300.1 RNA Sequence

  3. XR_929795.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    148479614..148536390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001378118.1: Suppressed sequence

    Description
    NM_001378118.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A096LP49.1 GenPept UniProtKB/Swiss-Prot:A0A096LP49

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