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gcat glycine C-acetyltransferase [ Danio rerio (zebrafish) ]

Gene ID: 402822, updated on 2-Nov-2024

Summary

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Official Symbol
gcatprovided by ZNC
Official Full Name
glycine C-acetyltransferaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060518-3
See related
Ensembl:ENSDARG00000005643 AllianceGenome:ZFIN:ZDB-GENE-060518-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable glycine C-acetyltransferase activity; ligase activity; and pyridoxal phosphate binding activity. Predicted to act upstream of or within biosynthetic process and threonine catabolic process. Predicted to be active in mitochondrion. Orthologous to human GCAT (glycine C-acetyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gcat in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (25990060..25998247)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (25859189..25867376)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110439128 Neighboring gene uncharacterized LOC101885347 Neighboring gene minichromosome maintenance complex component 5 Neighboring gene heme oxygenase 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Admixture Mapping of Alzheimer's disease in Caribbean Hispanics identifies a new locus on 22q13.1. Kizil C, et al. Mol Psychiatry, 2022 Jun. PMID 35365809, Free PMC Article
  2. Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression. Olsen AS, et al. Diabetes, 2012 Feb. PMID 22228713, Free PMC Article
  3. Parp inhibition prevents ten-eleven translocase enzyme activation and hyperglycemia-induced DNA demethylation. Dhliwayo N, et al. Diabetes, 2014 Sep. PMID 24722243, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycine C-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within threonine catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
NP_001166025.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172554.1 → NP_001166025.1  2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    BC067644, EB906064, EH467192
    UniProtKB/TrEMBL
    A0A8M1NT19, F6P2R4, Q6NWC4
    Related
    ENSDARP00000020361.6, ENSDART00000007398.7
    Conserved Domains (2) summary
    COG0156
    Location:40 → 420
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
    PRK06939
    Location:37 → 430
    PRK06939; 2-amino-3-ketobutyrate coenzyme A ligase; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    25990060..25998247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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