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mmadhcb metabolism of cobalamin associated Db [ Danio rerio (zebrafish) ]

Gene ID: 402886, updated on 2-Nov-2024

Summary

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Official Symbol
mmadhcbprovided by ZNC
Official Full Name
metabolism of cobalamin associated Dbprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040704-50
See related
Ensembl:ENSDARG00000005870 AllianceGenome:ZFIN:ZDB-GENE-040704-50
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
My011; mmadhc; zgc:91819
Summary
Predicted to act upstream of or within cobalamin metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblD. Orthologous to human MMADHC (metabolism of cobalamin associated D). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See mmadhcb in Genome Data Viewer
Location:
chromosome: 9
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (23049504..23056240)
105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (23238635..23245371)

Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450 family 27 subfamily A member 3 Neighboring gene Rho family GTPase 3b Neighboring gene LY6/PLAUR domain containing 6 Neighboring gene uncharacterized LOC137496471

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Many genes in fish have species-specific asymmetric rates of molecular evolution. Steinke D, et al. BMC Genomics, 2006 Feb 8. PMID 16466575, Free PMC Article
  2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cobalamin metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
metabolism of cobalamin associated Db
Names
metabolism of cobalamin associated D
methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205594.2 → NP_991157.2  metabolism of cobalamin associated Db

    Status: VALIDATED

    Source sequence(s)
    EH437230, EH459674, EH531169
    UniProtKB/TrEMBL
    A0A8M1PGE0, B0UYB6
    Related
    ENSDARP00000018012.7, ENSDART00000012478.9
    Conserved Domains (1) summary
    pfam10229
    Location:24 → 293
    DUF2246; Uncharacterized conserved protein (DUF2246)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007120.7 Reference GRCz11 Primary Assembly

    Range
    23049504..23056240
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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