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sult1st4 sulfotransferase family 1, cytosolic sulfotransferase 4 [ Danio rerio (zebrafish) ]

Gene ID: 402915, updated on 9-Dec-2024

Summary

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Official Symbol
sult1st4provided by ZNC
Official Full Name
sulfotransferase family 1, cytosolic sulfotransferase 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2054
See related
Ensembl:ENSDARG00000003181 AllianceGenome:ZFIN:ZDB-GENE-040426-2054
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:76922
Summary
Predicted to enable aryl sulfotransferase activity. Predicted to be involved in sulfation. Predicted to act upstream of or within catecholamine metabolic process. Predicted to be active in cytoplasm. Is expressed in caudal fin. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1A3 (sulfotransferase family 1A member 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
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Genomic context

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See sult1st4 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (53171006..53179639, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (53292427..53301104, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S25 Neighboring gene rabenosyn, RAB effector Neighboring gene gamma-aminobutyric acid type A receptor subunit delta Neighboring gene cilia and flagella associated protein 74

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of a novel zebrafish SULT1 cytosolic sulfotransferase: cloning, expression, characterization, and developmental expression study. Liu MY, et al. Arch Biochem Biophys, 2005 May 1. PMID 15820212
  2. Identification of a novel thyroid hormone-sulfating cytosolic sulfotransferase, SULT1 ST5, from zebrafish. Yasuda S, et al. FEBS J, 2005 Aug. PMID 16045754
  3. Role of SULT-mediated sulfation in the biotransformation of 2-butoxyethanol and sorbitan monolaurate: A study using zebrafish SULTs. Xi Y, et al. Aquat Toxicol, 2016 Aug. PMID 27218426
  4. A prototype of the mammalian sulfotransferase 1 (SULT1) family in Xenopus laevis: molecular and enzymatic properties of XlSULT1B.S. Yamauchi K, et al. Genes Genet Syst, 2019 Dec 10. PMID 31748465
  5. Sulfation of drug compounds by the zebrafish cytosolic sulfotransferases (SULTs). Kurogi K, et al. Drug Metab Lett, 2010 Apr. PMID 20446911

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within catecholamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sulfotransferase family 1, cytosolic sulfotransferase 4
NP_991183.1
XP_021333897.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_205620.2 → NP_991183.1  sulfotransferase family 1, cytosolic sulfotransferase 4

    See identical proteins and their annotated locations for NP_991183.1

    Status: PROVISIONAL

    Source sequence(s)
    BC066584
    UniProtKB/TrEMBL
    Q6XZC1
    Related
    ENSDARP00000035957.6, ENSDART00000030557.8
    Conserved Domains (1) summary
    pfam00685
    Location:46 → 297
    Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    53171006..53179639 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021478222.2 → XP_021333897.1  sulfotransferase family 1, cytosolic sulfotransferase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PQS2
    Conserved Domains (1) summary
    pfam00685
    Location:46 → 305
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein Strain
Heading Accession and Version

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