akt2l v-akt murine thymoma viral oncogene homolog 2, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: akt2lprovided by ZNC
Official Full Name: v-akt murine thymoma viral oncogene homolog 2, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040121-5
See related: AllianceGenome:ZFIN:ZDB-GENE-040121-5
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Is expressed in digestive system; lens; pectoral fin musculature; solid lens vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); high grade glioma; and reproductive organ cancer (multiple). Orthologous to human AKT2 (AKT serine/threonine kinase 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 10

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (311721..322769, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (311721..321124, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

G44976 (e-PCR)
- UniSTS:105778

fb71a08.y1 (e-PCR)
- UniSTS:191042

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables diacylglycerol-dependent serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: v-akt murine thymoma viral oncogene homolog 2, like

NP_997980.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212815.2 → NP_997980.1 v-akt murine thymoma viral oncogene homolog 2, like

See identical proteins and their annotated locations for NP_997980.1

Status: PROVISIONAL

Source sequence(s)

BC046892

UniProtKB/TrEMBL

Q802Y3

Conserved Domains (4) summary

cd05595
Location:153 → 475

STKc_PKB_beta; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2)

smart00220
Location:149 → 406

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01241
Location:4 → 111

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

pfam00169
Location:6 → 106

PH; PH domain