gnmt glycine N-methyltransferase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gnmtprovided by ZNC
Official Full Name: glycine N-methyltransferaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040227-1
See related: Ensembl:ENSDARG00000006840 AllianceGenome:ZFIN:ZDB-GENE-040227-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable cation binding activity; glycine N-methyltransferase activity; and identical protein binding activity. Predicted to be involved in several processes, including non-proteinogenic amino acid metabolic process; protein homotetramerization; and regulation of gluconeogenesis. Predicted to act upstream of or within methylation. Predicted to be active in cytosol. Is expressed in spinal cord. Human ortholog(s) of this gene implicated in glycine N-methyltransferase deficiency. Orthologous to human GNMT (glycine N-methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (48921829..48935872, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (48885702..48899745, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb02g11.x1 (e-PCR)
- UniSTS:202682

AI331885 (e-PCR)
- UniSTS:206790

fj25d09.y1 (e-PCR)
- UniSTS:198884

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables S-adenosyl-L-methionine binding	IBA Inferred from Biological aspect of Ancestor more info
enables folic acid binding	IEA Inferred from Electronic Annotation more info
enables glycine N-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycine binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylhomocysteine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in S-adenosylmethionine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein homotetramerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in sarcosine metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: glycine N-methyltransferase

NP_997981.1

EC 2.1.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.