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clasp2 cytoplasmic linker associated protein 2 [ Danio rerio (zebrafish) ]

Gene ID: 404604, updated on 9-Dec-2024

Summary

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Official Symbol
clasp2provided by ZNC
Official Full Name
cytoplasmic linker associated protein 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2343
See related
Ensembl:ENSDARG00000020345 AllianceGenome:ZFIN:ZDB-GENE-040426-2343
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:77279
Summary
Predicted to enable microtubule plus-end binding activity. Acts upstream of or within hematopoietic stem cell homeostasis. Predicted to be located in microtubule; ruffle membrane; and trans-Golgi network. Predicted to be active in basal cortex; kinetochore; and microtubule cytoskeleton. Orthologous to human CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
human mouse all
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Genomic context

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See clasp2 in Genome Data Viewer
Location:
chromosome: 19
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (42693558..42802301)
105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (43124121..43232869)

Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103909275 Neighboring gene sushi domain containing 5 Neighboring gene F-box and leucine-rich repeat protein 2 Neighboring gene upstream binding protein 1 Neighboring gene programmed cell death 6 interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Analysis of clasp2 Transcription Pattern in Male Germ Cells during Spermatogenesis: A Comparative Study in Zebrafish (Danio rerio) and Guppy (Poecilia reticulata). Ricci S, et al. Animals (Basel), 2023 Nov 22. PMID 38066968, Free PMC Article
  2. Identification of key genes involved in recovery from spinal cord injury in adult zebrafish. Shen WY, et al. Neural Regen Res, 2022 Jun. PMID 34782579, Free PMC Article
  3. CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development. Klaus A, et al. Cell Rep, 2022 Jun 14. PMID 35705037
  4. Crtap and p3h1 knock out zebrafish support defective collagen chaperoning as the cause of their osteogenesis imperfecta phenotype. Tonelli F, et al. Matrix Biol, 2020 Aug. PMID 32173581
  5. RNA-Seq analysis in mutant zebrafish reveals role of U1C protein in alternative splicing regulation. Rösel TD, et al. EMBO J, 2011 May 18. PMID 21468032, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development.
    Title: CLASP2 safeguards hematopoietic stem cell properties during mouse and fish development.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC77279

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables microtubule plus-end binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables tubulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of mitotic spindle localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exit from mitosis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within hematopoietic stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in microtubule anchoring ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule nucleation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in microtubule organizing center organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic spindle assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of microtubule polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of microtubule polymerization or depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of supramolecular fiber organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in basal cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell leading edge ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with mitotic spindle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in spindle microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
CLIP-associating protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328259.1 → NP_001315188.1  CLIP-associating protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    BX324146
    UniProtKB/TrEMBL
    A0A8M1P4L0, A0A8M3AVR1
    Conserved Domains (3) summary
    pfam02985
    Location:169 → 199
    HEAT; HEAT repeat
    pfam12348
    Location:337 → 538
    CLASP_N; CLASP N terminal
    sd00044
    Location:1332 → 1354
    HEAT; HEAT repeat [structural motif]

  2. NM_207072.2 → NP_996955.1  CLIP-associating protein 2 isoform 2

    See identical proteins and their annotated locations for NP_996955.1

    Status: VALIDATED

    Source sequence(s)
    BX324146
    UniProtKB/Swiss-Prot
    Q6NYW6
    UniProtKB/TrEMBL
    A0A8M3ASU6
    Related
    ENSDARP00000113962.1, ENSDART00000144557.3
    Conserved Domains (2) summary
    pfam12348
    Location:105 → 306
    CLASP_N; CLASP N terminal
    sd00044
    Location:1057 → 1079
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007130.7 Reference GRCz11 Primary Assembly

    Range
    42693558..42802301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017352210.3 → XP_017207699.1  CLIP-associating protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M3AVR1, A0A8M6YUG3

  2. XM_068215061.1 → XP_068071162.1  CLIP-associating protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8M3ASR7

  3. XM_009294394.4 → XP_009292669.1  CLIP-associating protein 2 isoform X13

    UniProtKB/TrEMBL
    A0A8M3AL48, A0A8M3AVS1
    Conserved Domains (3) summary
    pfam02985
    Location:169 → 199
    HEAT; HEAT repeat
    pfam12348
    Location:337 → 538
    CLASP_N; CLASP N terminal
    sd00044
    Location:1312 → 1334
    HEAT; HEAT repeat [structural motif]

  4. XM_068215073.1 → XP_068071174.1  CLIP-associating protein 2 isoform X16

    UniProtKB/TrEMBL
    A0A8M3AL48

  5. XM_068215060.1 → XP_068071161.1  CLIP-associating protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M3AVR1

  6. XM_068215062.1 → XP_068071163.1  CLIP-associating protein 2 isoform X4

    UniProtKB/TrEMBL
    A0A8M3ASR7

  7. XM_068215071.1 → XP_068071172.1  CLIP-associating protein 2 isoform X14

    UniProtKB/TrEMBL
    A0A8M3AL48

  8. XM_068215075.1 → XP_068071176.1  CLIP-associating protein 2 isoform X18

    UniProtKB/TrEMBL
    A0A8M3AL48

  9. XM_068215064.1 → XP_068071165.1  CLIP-associating protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A8M3B3Q9

  10. XM_068215076.1 → XP_068071177.1  CLIP-associating protein 2 isoform X19

    UniProtKB/TrEMBL
    A0A8M3B3R7

  11. XM_068215079.1 → XP_068071180.1  CLIP-associating protein 2 isoform X23

    UniProtKB/TrEMBL
    A0A8M3B3R7

  12. XM_068215066.1 → XP_068071167.1  CLIP-associating protein 2 isoform X8

    UniProtKB/TrEMBL
    A0A8M3AVR6

  13. XM_009294398.4 → XP_009292673.1  CLIP-associating protein 2 isoform X20

    UniProtKB/TrEMBL
    A0A8M3AL54, A0A8M3B3R7
    Conserved Domains (3) summary
    pfam02985
    Location:169 → 199
    HEAT; HEAT repeat
    pfam12348
    Location:337 → 538
    CLASP_N; CLASP N terminal
    sd00044
    Location:1303 → 1325
    HEAT; HEAT repeat [structural motif]

  14. XM_068215081.1 → XP_068071182.1  CLIP-associating protein 2 isoform X25

    UniProtKB/TrEMBL
    A0A8M3B3R7

  15. XM_068215072.1 → XP_068071173.1  CLIP-associating protein 2 isoform X15

    UniProtKB/TrEMBL
    A0A8M3AST0

  16. XM_068215077.1 → XP_068071178.1  CLIP-associating protein 2 isoform X21

    UniProtKB/TrEMBL
    A0A8M9PGC3

  17. XM_068215078.1 → XP_068071179.1  CLIP-associating protein 2 isoform X22

    UniProtKB/TrEMBL
    A0A8M9PRG1

  18. XM_068215085.1 → XP_068071186.1  CLIP-associating protein 2 isoform X30

    UniProtKB/TrEMBL
    A0A8M3AKF9

  19. XM_068215089.1 → XP_068071190.1  CLIP-associating protein 2 isoform X34

    UniProtKB/TrEMBL
    A0A8M9PN82

  20. XM_068215090.1 → XP_068071191.1  CLIP-associating protein 2 isoform X35

    UniProtKB/TrEMBL
    A0A8M3AL59

  21. XM_068215068.1 → XP_068071169.1  CLIP-associating protein 2 isoform X10

    UniProtKB/TrEMBL
    A0A8M3AKE9

  22. XM_068215082.1 → XP_068071183.1  CLIP-associating protein 2 isoform X26

    UniProtKB/TrEMBL
    A0A8M3AL48

  23. XM_009294400.4 → XP_009292675.1  CLIP-associating protein 2 isoform X29

    UniProtKB/TrEMBL
    A0A8M3AST4, A0A8M3AVT1
    Conserved Domains (4) summary
    pfam02985
    Location:169 → 199
    HEAT; HEAT repeat
    pfam12348
    Location:337 → 538
    CLASP_N; CLASP N terminal
    pfam17069
    Location:640 → 894
    RSRP; Arginine/Serine-Rich protein 1
    sd00044
    Location:1276 → 1298
    HEAT; HEAT repeat [structural motif]

  24. XM_068215088.1 → XP_068071189.1  CLIP-associating protein 2 isoform X33

    UniProtKB/TrEMBL
    A0A8M3B3S4

  25. XM_068215092.1 → XP_068071193.1  CLIP-associating protein 2 isoform X37

    UniProtKB/TrEMBL
    A0A8M6Z2X8

  26. XM_068215065.1 → XP_068071166.1  CLIP-associating protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A8M3ASS1

  27. XM_068215067.1 → XP_068071168.1  CLIP-associating protein 2 isoform X9

    UniProtKB/TrEMBL
    A0A8M3AL44

  28. XM_068215070.1 → XP_068071171.1  CLIP-associating protein 2 isoform X12

    UniProtKB/TrEMBL
    A0A8M3B3R3

  29. XM_068215080.1 → XP_068071181.1  CLIP-associating protein 2 isoform X24

    UniProtKB/TrEMBL
    A0A8M3B3R3

  30. XM_068215084.1 → XP_068071185.1  CLIP-associating protein 2 isoform X28

    UniProtKB/TrEMBL
    A0A8M3AVS6

  31. XM_068215086.1 → XP_068071187.1  CLIP-associating protein 2 isoform X31

    UniProtKB/TrEMBL
    A0A8M3B3S1

  32. XM_009294405.4 → XP_009292680.1  CLIP-associating protein 2 isoform X38

    UniProtKB/TrEMBL
    A0A8M3ASU0, A0A8M3AVT1
    Related
    ENSDARP00000117340.1, ENSDART00000136873.3
    Conserved Domains (3) summary
    pfam02985
    Location:169 → 199
    HEAT; HEAT repeat
    pfam12348
    Location:337 → 538
    CLASP_N; CLASP N terminal
    sd00044
    Location:1258 → 1280
    HEAT; HEAT repeat [structural motif]

  33. XM_068215093.1 → XP_068071194.1  CLIP-associating protein 2 isoform X39

    UniProtKB/TrEMBL
    A0A8M3B3S4

  34. XM_068215063.1 → XP_068071164.1  CLIP-associating protein 2 isoform X5

    UniProtKB/TrEMBL
    A0A8M3AKE5

  35. XM_068215087.1 → XP_068071188.1  CLIP-associating protein 2 isoform X32

    UniProtKB/TrEMBL
    A0A8M2B6H8

  36. XM_068215083.1 → XP_068071184.1  CLIP-associating protein 2 isoform X27

    UniProtKB/TrEMBL
    A0A8M2B6H8

  37. XM_068215100.1 → XP_068071201.1  CLIP-associating protein 2 isoform X46

    UniProtKB/TrEMBL
    A0A8M2B6H8

  38. XM_068215096.1 → XP_068071197.1  CLIP-associating protein 2 isoform X42

    UniProtKB/TrEMBL
    A0A8M6YTV4

  39. XM_068215095.1 → XP_068071196.1  CLIP-associating protein 2 isoform X41

    UniProtKB/TrEMBL
    A0A8M6YTV4

  40. XM_068215069.1 → XP_068071170.1  CLIP-associating protein 2 isoform X11

    UniProtKB/TrEMBL
    A0A8M9PAW3

  41. XM_068215091.1 → XP_068071192.1  CLIP-associating protein 2 isoform X36

    UniProtKB/TrEMBL
    A0A8M3AKG2

  42. XM_068215097.1 → XP_068071198.1  CLIP-associating protein 2 isoform X43

    UniProtKB/TrEMBL
    A0A8M6YTV4

  43. XM_068215074.1 → XP_068071175.1  CLIP-associating protein 2 isoform X17

    UniProtKB/TrEMBL
    A0A8M3AKF4

  44. XM_068215094.1 → XP_068071195.1  CLIP-associating protein 2 isoform X40

    UniProtKB/TrEMBL
    A0A8M3B3S4

  45. XM_068215098.1 → XP_068071199.1  CLIP-associating protein 2 isoform X44

    UniProtKB/TrEMBL
    A0A8M6YTV4

  46. XM_068215099.1 → XP_068071200.1  CLIP-associating protein 2 isoform X45

    UniProtKB/TrEMBL
    A0A8M6YTV4

  47. XM_068215101.1 → XP_068071202.1  CLIP-associating protein 2 isoform X48

    UniProtKB/TrEMBL
    A0A8M3AKG9

  48. XM_068215102.1 → XP_068071203.1  CLIP-associating protein 2 isoform X49

    UniProtKB/TrEMBL
    A0A8M3AKG9
    Related
    ENSDARP00000116634.1, ENSDART00000139109.3

  49. XM_009294413.4 → XP_009292688.1  CLIP-associating protein 2 isoform X47

    UniProtKB/TrEMBL
    A0A8M3AL68, A0A8M3B3S6
    Conserved Domains (2) summary
    pfam12348
    Location:109 → 310
    CLASP_N; CLASP N terminal
    sd00044
    Location:1030 → 1052
    HEAT; HEAT repeat [structural motif]

  50. XM_068215103.1 → XP_068071204.1  CLIP-associating protein 2 isoform X50

    UniProtKB/TrEMBL
    A0A8M3B3S6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NYW6.1 GenPept UniProtKB/Swiss-Prot:Q6NYW6

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