adhfe1 alcohol dehydrogenase iron containing 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adhfe1provided by ZNC
Official Full Name: alcohol dehydrogenase iron containing 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2070
See related: Ensembl:ENSDARG00000053518 AllianceGenome:ZFIN:ZDB-GENE-040426-2070
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:77479
Summary: Predicted to enable alcohol dehydrogenase (NAD+) activity. Predicted to be active in mitochondrion. Is expressed in female organism. Orthologous to human ADHFE1 (alcohol dehydrogenase iron containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (42095487..42109575, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (42246069..42260157, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables alcohol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables alcohol dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables hydroxyacid-oxoacid transhydrogenase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hydroxyacid-oxoacid transhydrogenase, mitochondrial

NP_996969.1

EC 1.1.99.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207086.1 → NP_996969.1 hydroxyacid-oxoacid transhydrogenase, mitochondrial

See identical proteins and their annotated locations for NP_996969.1

Status: PROVISIONAL

Source sequence(s)

BC066529

UniProtKB/TrEMBL

Q6NYM8

Related

ENSDARP00000070033.4, ENSDART00000075551.6

Conserved Domains (1) summary

cd08190
Location:55 → 468

HOT; Hydroxyacid-oxoacid transhydrogenase (HOT) involved in gamma-hydroxybutyrate metabolism