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oclna occludin a [ Danio rerio (zebrafish) ]

Gene ID: 405757, updated on 2-Nov-2024

Summary

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Official Symbol
oclnaprovided by ZNC
Official Full Name
occludin aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2685
See related
Ensembl:ENSDARG00000005108 AllianceGenome:ZFIN:ZDB-GENE-040426-2685
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ocln; zgc:56359; wu:fd23h10; wu:fi13c01; zgc:113992
Summary
Predicted to be involved in bicellular tight junction assembly. Predicted to be located in anchoring junction and plasma membrane. Predicted to be active in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including EVL; digestive system; musculature system; pleuroperitoneal region; and sensory system. Human ortholog(s) of this gene implicated in Crohn's disease and pseudo-TORCH syndrome 1. Orthologous to human OCLN (occludin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See oclna in Genome Data Viewer
Location:
chromosome: 10
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (2924775..2942926, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (2897604..2915755, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene cell cycle and apoptosis regulator 2 Neighboring gene endoplasmic reticulum aminopeptidase 1a Neighboring gene MARVEL domain containing 2a Neighboring gene uncharacterized LOC137496551 Neighboring gene zinc finger, FYVE domain containing 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cortisol regulates epithelial permeability and sodium losses in zebrafish exposed to acidic water. Kwong RW, et al. J Endocrinol, 2013 Jun. PMID 23503775
  2. Genetic control of single lumen formation in the zebrafish gut. Bagnat M, et al. Nat Cell Biol, 2007 Aug. PMID 17632505
  3. Bacterial induction of Snail1 contributes to blood-brain barrier disruption. Kim BJ, et al. J Clin Invest, 2015 Jun. PMID 25961453, Free PMC Article
  4. Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio). Jia J, et al. Biochem Biophys Res Commun, 2018 May 5. PMID 29574160
  5. Antibiotic-Driven Gut Microbiome Disorder Alters the Effects of Sinomenine on Morphine-Dependent Zebrafish. Chen Z, et al. Front Microbiol, 2020. PMID 32670209, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56359, MGC113992

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within bicellular tight junction assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
occludin
NP_997997.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212832.2 → NP_997997.2  occludin

    Status: VALIDATED

    Source sequence(s)
    CR394525
    UniProtKB/TrEMBL
    A0A8M1PI39, F1R799
    Related
    ENSDARP00000010183.6, ENSDART00000002622.7
    Conserved Domains (2) summary
    pfam01284
    Location:40 → 217
    MARVEL; Membrane-associating domain
    pfam07303
    Location:393 → 488
    Occludin_ELL; Occludin homology domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    2924775..2942926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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