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blnk B cell linker [ Danio rerio (zebrafish) ]

Gene ID: 405764, updated on 4-Jan-2025

Summary

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Official Symbol
blnkprovided by ZNC
Official Full Name
B cell linkerprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040702-4
See related
Ensembl:ENSDARG00000042722 AllianceGenome:ZFIN:ZDB-GENE-040702-4
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Human ortholog(s) of this gene implicated in agammaglobulinemia and agammaglobulinemia 4. Orthologous to human BLNK (B cell linker). [provided by Alliance of Genome Resources, Jan 2025]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See blnk in Genome Data Viewer
Location:
chromosome: 13
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (50520563..50567658, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (50203896..50252739, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 137Ba Neighboring gene uncharacterized LOC101883869 Neighboring gene E3 SUMO-protein ligase ZBED1-like Neighboring gene cyclin J Neighboring gene microRNA 202 Neighboring gene ventral expressed homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The manipulation of cell suspensions from zebrafish intestinal mucosa contributes to understanding enteritis. Zhao X, et al. Front Immunol, 2023. PMID 37251394, Free PMC Article
  2. Simultaneous B and T cell acute lymphoblastic leukemias in zebrafish driven by transgenic MYC: implications for oncogenesis and lymphopoiesis. Borga C, et al. Leukemia, 2019 Feb. PMID 30111845, Free PMC Article
  3. Single-Cell RNA Sequencing Reveals Size-Dependent Effects of Polystyrene Microplastics on Immune and Secretory Cell Populations from Zebrafish Intestines. Gu W, et al. Environ Sci Technol, 2020 Mar 17. PMID 32092251
  4. Zebrafish B cell acute lymphoblastic leukemia: new findings in an old model. Park G, et al. Oncotarget, 2020 Apr 14. PMID 32341750, Free PMC Article
  5. Stat5b Regulates Sexually Dimorphic Gene Expression in Zebrafish Liver. Huang P, et al. Front Physiol, 2018. PMID 29904357, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

General protein information

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Preferred Names
B-cell linker protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212838.1 → NP_998003.1  B-cell linker protein

    See identical proteins and their annotated locations for NP_998003.1

    Status: PROVISIONAL

    Source sequence(s)
    AF388205
    UniProtKB/TrEMBL
    Q8JI35
    Related
    ENSDARP00000062683.5, ENSDART00000062684.7
    Conserved Domains (1) summary
    cd09929
    Location:369 → 489
    SH2_BLNK_SLP-76; Src homology 2 (SH2) domain found in B-cell linker (BLNK) protein and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    50520563..50567658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017358727.2 → XP_017214216.1  B-cell linker protein isoform X1

    UniProtKB/TrEMBL
    A0A8M6Z948
Nucleotide Protein Strain
Heading Accession and Version

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