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agmo alkylglycerol monooxygenase [ Danio rerio (zebrafish) ]

Gene ID: 405819, updated on 2-Nov-2024

Summary

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Official Symbol
agmoprovided by ZNC
Official Full Name
alkylglycerol monooxygenaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2207
See related
Ensembl:ENSDARG00000025595 AllianceGenome:ZFIN:ZDB-GENE-040426-2207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tmem195; zgc:77121
Summary
Predicted to enable glyceryl-ether monooxygenase activity and iron ion binding activity. Predicted to be involved in ether lipid metabolic process and membrane lipid metabolic process. Predicted to act upstream of or within lipid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human AGMO (alkylglycerol monooxygenase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See agmo in Genome Data Viewer
Location:
chromosome: 15
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34334721..34418525, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (34476752..34560556, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene ETS variant transcription factor 1 Neighboring gene uncharacterized LOC137487770 Neighboring gene diacylglycerol kinase, beta Neighboring gene mesenchyme homeobox 2a Neighboring gene CDP-L-ribitol pyrophosphorylase A Neighboring gene sclerostin domain containing 1a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A Vegfc-Emilin2a-Cxcl8a Signaling Axis Required for Zebrafish Cardiac Regeneration. El-Sammak H, et al. Circ Res, 2022 Apr. PMID 35264012, Free PMC Article
  2. Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. O'Hare EA, et al. Mol Endocrinol, 2016 Apr. PMID 26963759, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC77121

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glyceryl-ether monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glyceryl-ether monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables glyceryl-ether monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ether lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in membrane lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alkylglycerol monooxygenase
Names
transmembrane protein 195
NP_998048.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212883.2 → NP_998048.2  alkylglycerol monooxygenase

    Status: VALIDATED

    Source sequence(s)
    BX470068, CK028737, CN511695, EH513834, EH597521
    UniProtKB/Swiss-Prot
    Q6NYE4
    UniProtKB/TrEMBL
    A0A8M1PI86
    Related
    ENSDARP00000122798.1, ENSDART00000147582.3
    Conserved Domains (2) summary
    COG3000
    Location:91 → 252
    ERG3; Sterol desaturase/sphingolipid hydroxylase, fatty acid hydroxylase superfamily [Lipid transport and metabolism]
    pfam04116
    Location:118 → 248
    FA_hydroxylase; Fatty acid hydroxylase superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    34334721..34418525 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NYE4.1 GenPept UniProtKB/Swiss-Prot:Q6NYE4

Gene LinkOut

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