lgals2a lectin, galactoside-binding, soluble, 2a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: lgals2aprovided by ZNC
Official Full Name: lectin, galactoside-binding, soluble, 2aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050318-2
See related: Ensembl:ENSDARG00000054942 AllianceGenome:ZFIN:ZDB-GENE-050318-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lgals1l2; Drgal1-L2; zgc:86752
Summary: Enables galactoside binding activity and laminin binding activity. Acts upstream of or within several processes, including positive regulation of neurogenesis; skeletal muscle fiber development; and sprouting angiogenesis. Predicted to be active in extracellular space. Is expressed in digestive system; musculature system; nervous system; notochord; and spleen. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human LGALS2 (galectin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 3

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	3	NC_007114.7 (28953275..28960244)
105	previous assembly	GRCz10 (GCF_000002035.5)	3	NC_007114.6 (28822433..28829402)

Chromosome 3 - NC_007114.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

X-ray diffraction data from crystals of zebrafish Drgal1-L2 were collected to a resolution of 1.5A.
Title: Crystallization and preliminary X-ray crystallographic analysis of zebrafish prototype galectin Drgal1-L2.
Knockdown experiments in zebrafish embryos using a morpholino-modified antisense oligo targeted to the 5'-UTR sequence of Drgal1-L2 resulted in a phenotype with a bent tail and disorganized muscle fibers.
Title: Knockdown of a galectin-1-like protein in zebrafish (Danio rerio) causes defects in skeletal muscle development.
Drgal1-L2 is expressed postbud stage, and its expression is strikingly specific to the notochord
Title: Biochemical and molecular characterization of galectins from zebrafish (Danio rerio): notochord-specific expression of a prototype galectin during early embryogenesis.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carbohydrate binding	IBA Inferred from Biological aspect of Ancestor more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables galactoside binding	IBA Inferred from Biological aspect of Ancestor more info
enables galactoside binding	IDA Inferred from Direct Assay more info	PubMed
enables galactoside binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables laminin binding	IBA Inferred from Biological aspect of Ancestor more info
enables laminin binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of wound healing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lectin, galactoside-binding, soluble, 2a

Names: lectin, galactoside-binding, soluble, 1 (galectin 1)-like 2; proto galectin Gal1-L2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212894.2 → NP_998059.2 lectin, galactoside-binding, soluble, 2a

See identical proteins and their annotated locations for NP_998059.2

Status: VALIDATED

Source sequence(s)

BI708608, BX908785, EH454585

UniProtKB/TrEMBL

A0A8M1PIA3, Q6IQI2, Q6TGN5

Related

ENSDARP00000094378.2, ENSDART00000103602.5

Conserved Domains (1) summary

cd00070
Location:10 → 132

GLECT; Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may ...