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wrnip1 WRN helicase interacting protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 405856, updated on 4-Jan-2025

Summary

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Official Symbol
wrnip1provided by ZNC
Official Full Name
WRN helicase interacting protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2415
See related
Ensembl:ENSDARG00000005218 AllianceGenome:ZFIN:ZDB-GENE-040426-2415
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:85976
Summary
Predicted to enable enzyme activator activity and single-stranded DNA helicase activity. Predicted to be involved in DNA synthesis involved in DNA repair and DNA-templated DNA replication. Predicted to act upstream of or within DNA repair and DNA replication. Predicted to be active in nucleus. Orthologous to human WRNIP1 (WRN helicase interacting protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See wrnip1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (374365..389813, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (361498..376946, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene si:dkey-33c14.6 Neighboring gene si:dkey-33c14.7 Neighboring gene myosin light chain kinase family, member 4a Neighboring gene uncharacterized LOC137487622

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Banp regulates DNA damage response and chromosome segregation during the cell cycle in zebrafish retina. Babu S, et al. Elife, 2022 Aug 9. PMID 35942692, Free PMC Article
  2. The Axenfeld-Rieger Syndrome Gene FOXC1 Contributes to Left-Right Patterning. Chrystal PW, et al. Genes (Basel), 2021 Jan 26. PMID 33530637, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC85976

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables enzyme activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA synthesis involved in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA-templated DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ATPase WRNIP1
Names
Werner helicase interacting protein 1
NP_998085.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212920.1 → NP_998085.1  ATPase WRNIP1

    See identical proteins and their annotated locations for NP_998085.1

    Status: PROVISIONAL

    Source sequence(s)
    BC067729
    UniProtKB/TrEMBL
    A0A8M1PFZ7, Q6NW46
    Related
    ENSDARP00000010591.5, ENSDART00000004848.7
    Conserved Domains (5) summary
    PRK13342
    Location:116 → 544
    PRK13342; recombination factor protein RarA; Reviewed
    pfam00004
    Location:154 → 268
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam12002
    Location:391 → 546
    MgsA_C; MgsA AAA+ ATPase C terminal
    pfam16193
    Location:307 → 390
    AAA_assoc_2; AAA C-terminal domain
    cl21455
    Location:134 → 172
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    374365..389813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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