pccb propionyl-CoA carboxylase subunit beta [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pccbprovided by ZNC
Official Full Name: propionyl-CoA carboxylase subunit betaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2467
See related: Ensembl:ENSDARG00000038910 AllianceGenome:ZFIN:ZDB-GENE-040426-2467
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:85813
Summary: Predicted to enable propionyl-CoA carboxylase activity. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Is expressed in several structures, including alar plate midbrain region; musculature system; optic tectum; optic vesicle; and pronephros. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and propionic acidemia. Orthologous to human PCCB (propionyl-CoA carboxylase subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (25108576..25120032, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (25452935..25464417, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables propionyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables propionyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: propionyl-CoA carboxylase beta chain, mitochondrial

Names: propionyl CoA carboxylase, beta polypeptide; propionyl Coenzyme A carboxylase, beta polypeptide

NP_998090.1

EC 6.4.1.3

XP_005163429.1

EC 6.4.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212925.1 → NP_998090.1 propionyl-CoA carboxylase beta chain, mitochondrial

See identical proteins and their annotated locations for NP_998090.1

Status: PROVISIONAL

Source sequence(s)

BC067640

UniProtKB/TrEMBL

Q6NWC8

Conserved Domains (2) summary

COG4799
Location:53 → 543

MmdA; Acetyl-CoA carboxylase, carboxyltransferase component [Lipid transport and metabolism]

cl23717
Location:79 → 275

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

25108576..25120032 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005163372.5 → XP_005163429.1 propionyl-CoA carboxylase beta chain, mitochondrial isoform X1

UniProtKB/TrEMBL

A0A8M2BAE9, B0V0X1

Related

ENSDARP00000116664.1, ENSDART00000132549.4

Conserved Domains (2) summary

COG4799
Location:53 → 555

MmdA; Acetyl-CoA carboxylase, carboxyltransferase component [Lipid transport and metabolism]

cl23717
Location:79 → 275

crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...