nrp2b neuropilin 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nrp2bprovided by ZNC
Official Full Name: neuropilin 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040611-3
See related: Ensembl:ENSDARG00000038446 AllianceGenome:ZFIN:ZDB-GENE-040611-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: npn-2B; sb:cb513; id:ibd2759
Summary: Predicted to enable semaphorin receptor activity. Acts upstream of or within several processes, including axon development; regulation of vascular endothelial growth factor receptor signaling pathway; and vasculogenesis. Predicted to be located in membrane. Predicted to be active in axon; glutamatergic synapse; and postsynaptic membrane. Is expressed in several structures, including head; mesoderm; nervous system; neural crest cell; and neural plate. Orthologous to human NRP2 (neuropilin 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 9

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (14367578..14504834, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (14396375..14533717, complement)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This paper shows that Nrp1a is required for Sema3D repulsion of or111-7 transgene-labeled sensory neurons, and Nrp2b contributes to their targeting through an independent signaling pathway mediated by an as yet unidentified ligand.
Title: Attractant and repellent cues cooperate in guiding a subset of olfactory sensory axons to a well-defined protoglomerular target.

Submit: New GeneRIF Correction

General gene information

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Markers

z48680 (e-PCR), detects polymorphism
- UniSTS:238647

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info
enables vascular endothelial growth factor receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axonal fasciculation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural crest cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within olfactory bulb axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within olfactory bulb axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vascular endothelial growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vascular endothelial growth factor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: neuropilin-2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212966.1 → NP_998131.1 neuropilin-2b precursor

See identical proteins and their annotated locations for NP_998131.1

Status: PROVISIONAL

Source sequence(s)

AY428802

UniProtKB/TrEMBL

Q6T867

Related

ENSDARP00000056102.6, ENSDART00000056103.8

Conserved Domains (4) summary

cd00041
Location:26 → 139

CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

cd00057
Location:276 → 423

FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

pfam00629
Location:630 → 779

MAM; MAM domain, meprin/A5/mu

pfam11980
Location:842 → 920

DUF3481; C-terminal domain of neuropilin glycoprotein