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xpnpep1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble [ Danio rerio (zebrafish) ]

Gene ID: 406253, updated on 2-Nov-2024

Summary

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Official Symbol
xpnpep1provided by ZNC
Official Full Name
X-prolyl aminopeptidase (aminopeptidase P) 1, solubleprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-999
See related
Ensembl:ENSDARG00000029011 AllianceGenome:ZFIN:ZDB-GENE-040426-999
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fa02e02; zgc:56366; zgc:77772; wu:fa02e02
Summary
Predicted to enable metalloaminopeptidase activity. Predicted to act upstream of or within proteolysis. Predicted to be located in cytoplasm. Is expressed in intestine and liver. Orthologous to human XPNPEP1 (X-prolyl aminopeptidase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See xpnpep1 in Genome Data Viewer
Location:
chromosome: 22
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (27092469..27115219, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (27230017..27252767, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene chemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1) Neighboring gene rho-associated protein kinase 2-like Neighboring gene si:dkey-246e1.3 Neighboring gene Copper-only SOD repeat protein Neighboring gene uncharacterized LOC137488949 Neighboring gene si:dkey-208m12.2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of a plant isoflavonoid that causes biliary atresia. Lorent K, et al. Sci Transl Med, 2015 May 6. PMID 25947162, Free PMC Article
  2. Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. Tang V, et al. J Pediatr Gastroenterol Nutr, 2016 Nov. PMID 27526058, Free PMC Article
  3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC56366

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloaminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
xaa-Pro aminopeptidase 1
NP_998145.1
XP_021324983.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_212980.1 → NP_998145.1  xaa-Pro aminopeptidase 1

    See identical proteins and their annotated locations for NP_998145.1

    Status: PROVISIONAL

    Source sequence(s)
    BC064889
    UniProtKB/TrEMBL
    A0A8M1PEE0, Q6P1S3
    Related
    ENSDARP00000022971.7, ENSDART00000019442.9
    Conserved Domains (5) summary
    COG0006
    Location:149 → 566
    PepP; Xaa-Pro aminopeptidase [Amino acid transport and metabolism]
    cd01085
    Location:329 → 550
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:557 → 619
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:164 → 326
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:10 → 154
    Creatinase_N; Creatinase/Prolidase N-terminal domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    27092469..27115219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021469308.1 → XP_021324983.1  xaa-Pro aminopeptidase 1 isoform X1

    UniProtKB/TrEMBL
    A0A286Y8E9, A0A8M9PDT8
    Related
    ENSDARP00000143421.1, ENSDART00000178855.2
    Conserved Domains (4) summary
    cd01085
    Location:334 → 555
    APP; X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline, ...
    pfam16188
    Location:562 → 624
    Peptidase_M24_C; C-terminal region of peptidase_M24
    pfam16189
    Location:162 → 331
    Creatinase_N_2; Creatinase/Prolidase N-terminal domain
    cl23800
    Location:15 → 159
    Creatinase_N; Creatinase/Prolidase N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

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