itpk1a inositol-tetrakisphosphate 1-kinase a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: itpk1aprovided by ZNC
Official Full Name: inositol-tetrakisphosphate 1-kinase aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1953
See related: Ensembl:ENSDARG00000013056 AllianceGenome:ZFIN:ZDB-GENE-040426-1953
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: itpk1; zgc:56075; wu:fj15d08
Summary: Predicted to enable inositol phosphate kinase activity. Predicted to be involved in necroptotic process. Predicted to act upstream of or within inositol trisphosphate metabolic process and phosphorylation. Is expressed in gut; lens; lens placode; and solid lens vesicle. Orthologous to human ITPK1 (inositol-tetrakisphosphate 1-kinase). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (27049523..27086143, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (27150433..27187065, complement)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4,5-tetrakisphosphate 6-kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables inositol-1,3,4-trisphosphate 5-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,3,4-trisphosphate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-1,3,4-trisphosphate 6-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,3,4-trisphosphate 6-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-3,4,5,6-tetrakisphosphate 1-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-3,4,5,6-tetrakisphosphate 1-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol-3,4,6-trisphosphate 1-kinase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within inositol trisphosphate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in necroptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inositol-tetrakisphosphate 1-kinase

Names: inositol 1,3,4-triphosphate 5/6 kinase; inositol 1,3,4-trisphosphate 5/6-kinase; inositol-triphosphate 5/6-kinase; ins(1,3,4)P(3) 5/6-kinase

NP_998182.1

EC 2.7.1.134

EC 2.7.1.159

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.