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pik3r3a phosphoinositide-3-kinase, regulatory subunit 3a (gamma) [ Danio rerio (zebrafish) ]

Gene ID: 406311, updated on 2-Nov-2024

Summary

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Official Symbol
pik3r3aprovided by ZNC
Official Full Name
phosphoinositide-3-kinase, regulatory subunit 3a (gamma)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1978
See related
Ensembl:ENSDARG00000103038 AllianceGenome:ZFIN:ZDB-GENE-040426-1978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:73230; wu:fb16a12; wu:fk56b03
Summary
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in insulin receptor signaling pathway. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See pik3r3a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (2957516..2988713)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (3115627..3146824)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene leucine-rich repeat-containing protein 38 Neighboring gene zyg-11 family member, cell cycle regulator, like Neighboring gene intracisternal A particle-promoted polypeptide Neighboring gene guanylate kinase 1a Neighboring gene zgc:63882

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Transcriptome analysis reveals functional roles of nacreous protein N16 in prednisolone-induced osteoporotic zebrafish. Lin JB, et al. Int J Biol Macromol, 2019 Feb 1. PMID 30219513
  2. Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS. Tingaud-Sequeira A, et al. Mol Genet Genomic Med, 2020 Oct. PMID 32738032, Free PMC Article
  3. Immunotoxicity of β-Diketone Antibiotic Mixtures to Zebrafish (Danio rerio) by Transcriptome Analysis. Li F, et al. PLoS One, 2016. PMID 27046191, Free PMC Article
  4. An integrated approach with the zebrafish model for biomonitoring of municipal wastewater effluent and receiving waters. Li C, et al. Water Res, 2018 Mar 15. PMID 29258003
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of phosphatidylinositol 3-kinase complex, class IA IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphoinositide-3-kinase, regulatory subunit 3a (gamma)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291329.1 → NP_001278258.1  phosphoinositide-3-kinase, regulatory subunit 3a (gamma)

    See identical proteins and their annotated locations for NP_001278258.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    EH456435, FP102774
    UniProtKB/TrEMBL
    A0A0R4IUJ2, A0A8M1P174
    Related
    ENSDARP00000130273.1, ENSDART00000160715.2
    Conserved Domains (3) summary
    cd09930
    Location:224 → 327
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cl15255
    Location:36 → 145
    SH2; Src homology 2 (SH2) domain
    cl23765
    Location:153 → 212
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

  2. NM_213038.2 → NP_998203.2  phosphoinositide-3-kinase, regulatory subunit 3a (gamma)

    See identical proteins and their annotated locations for NP_998203.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    CB359701, EH456435, FP102774
    UniProtKB/TrEMBL
    A0A0R4IUJ2, A0A8M1P174
    Related
    ENSDARP00000140757.1, ENSDART00000167649.2
    Conserved Domains (3) summary
    cd09930
    Location:224 → 327
    SH2_cSH2_p85_like; C-terminal Src homology 2 (cSH2) domain found in p85
    cl15255
    Location:36 → 145
    SH2; Src homology 2 (SH2) domain
    cl23765
    Location:153 → 212
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    2957516..2988713
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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