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wdr24 WD repeat domain 24 [ Danio rerio (zebrafish) ]

Gene ID: 406336, updated on 2-Nov-2024

Summary

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Official Symbol
wdr24provided by ZNC
Official Full Name
WD repeat domain 24provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2012
See related
Ensembl:ENSDARG00000025507 AllianceGenome:ZFIN:ZDB-GENE-040426-2012
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:55946; wu:fd05f12
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and protein K6-linked ubiquitination. Predicted to act upstream of or within autophagy and positive regulation of TOR signaling. Predicted to be located in lysosomal membrane. Predicted to be part of GATOR2 complex. Predicted to be active in cytosol and vacuolar membrane. Orthologous to human WDR24 (WD repeat domain 24). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See wdr24 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (37640698..37661073)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (37752768..37772762)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene rhomboid, veinlet-like 1 (Drosophila) Neighboring gene zgc:112496 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene zgc:112185

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death. Tucker SK, et al. Development, 2024 Mar 15. PMID 38512806,
  2. Early leucine programming on protein utilization and mTOR signaling by DNA methylation in zebrafish (Danio rerio). Zhu QS, et al. Nutr Metab (Lond), 2020. PMID 32818036, Free PMC Article
  3. Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3. Hart DO, et al. Nature, 2007 Dec 13. PMID 18046332, Free PMC Article
  4. Analysis of DNA methylation reveals a partial reprogramming of the Müller glia genome during retina regeneration. Powell C, et al. Proc Natl Acad Sci U S A, 2013 Dec 3. PMID 24248357, Free PMC Article
  5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to amino acid starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within positive regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of TORC1 signaling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K6-linked ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of GATOR2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GATOR2 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in vacuolar membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GATOR2 complex protein WDR24
Names
GATOR complex protein WDR24
WD repeat-containing protein 24
NP_998228.1
XP_005162936.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213063.1 → NP_998228.1  GATOR2 complex protein WDR24

    See identical proteins and their annotated locations for NP_998228.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045501
    UniProtKB/Swiss-Prot
    Q7ZVL2
    Related
    ENSDARP00000008451.8, ENSDART00000008047.10
    Conserved Domains (4) summary
    COG2319
    Location:51 → 318
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:118 → 155
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:82 → 318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl24077
    Location:718 → 776
    Zn_ribbon_17; Zinc-ribbon, C4HC2 type

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    37640698..37661073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005162879.5 → XP_005162936.1  GATOR2 complex protein WDR24 isoform X1

    UniProtKB/TrEMBL
    A0A8M2B9U3
    Conserved Domains (4) summary
    COG2319
    Location:51 → 318
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:118 → 155
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:82 → 318
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl24077
    Location:717 → 775
    Zn_ribbon_17; Zinc-ribbon, C4HC2 type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZVL2.1 GenPept UniProtKB/Swiss-Prot:Q7ZVL2

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