tcirg1b T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tcirg1bprovided by ZNC
Official Full Name: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2022
See related: Ensembl:ENSDARG00000105142 AllianceGenome:ZFIN:ZDB-GENE-040426-2022
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tcirg1; zgc:55891; wu:fb44e06; wu:fi46h07
Summary: Predicted to enable ATPase binding activity. Predicted to be involved in vacuolar acidification. Predicted to act upstream of or within proton transmembrane transport. Predicted to be located in membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase complex. Predicted to be active in plasma membrane. Is expressed in macrophage and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 1. Orthologous to human TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (16777314..16810493, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (16472060..16504786, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fi46h07.x1 (e-PCR)
- UniSTS:204614

fb44e06.x1 (e-PCR)
- UniSTS:203214

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables proton-transporting ATPase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in vacuolar acidification	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info
part_of vacuolar proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of vacuolar proton-transporting V-type ATPase, V0 domain	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b

Names: T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3b; a3 subunit of vacuolar-adenosine triphosphatase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213069.1 → NP_998234.1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b

See identical proteins and their annotated locations for NP_998234.1

Status: PROVISIONAL

Source sequence(s)

BC045484

UniProtKB/TrEMBL

Q7ZVM7

Related

ENSDARP00000133899.1, ENSDART00000170758.2

Conserved Domains (2) summary

COG1269
Location:27 → 812

NtpI; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]

pfam01496
Location:28 → 814

V_ATPase_I; V-type ATPase 116kDa subunit family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

16777314..16810493 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068213184.1 → XP_068069285.1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b isoform X2
XM_068213182.1 → XP_068069283.1 T cell immune regulator 1, ATPase H+ transporting V0 subunit a3b isoform X1