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cyb5a cytochrome b5 type A (microsomal) [ Danio rerio (zebrafish) ]

Gene ID: 406409, updated on 2-Nov-2024

Summary

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Official Symbol
cyb5aprovided by ZNC
Official Full Name
cytochrome b5 type A (microsomal)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2148
See related
Ensembl:ENSDARG00000098589 AllianceGenome:ZFIN:ZDB-GENE-040426-2148
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cyb5; zgc:64123; wu:fb44a11
Summary
Enables heme binding activity and oxidoreductase activity. Acts upstream of or within cellular response to xenobiotic stimulus. Predicted to be active in intracellular membrane-bounded organelle and membrane. Is expressed in digestive system; head; immature eye; neural crest; and optic stalk. Human ortholog(s) of this gene implicated in methemoglobinemia and methemoglobinemia and ambiguous genitalia. Orthologous to human CYB5A (cytochrome b5 type A). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cyb5a in Genome Data Viewer
Location:
chromosome: 24
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (2836307..2843039, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (2837562..2844354, complement)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene phenylalanyl-tRNA synthetase 2, mitochondrial Neighboring gene LYR motif containing 4 Neighboring gene si:ch211-152c8.5 Neighboring gene si:ch211-152c8.2 Neighboring gene divergent protein kinase domain 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2. Pallan PS, et al. J Biol Chem, 2015 Feb 6. PMID 25533464, Free PMC Article
  2. The Zebrafish Cytochrome b(5)/Cytochrome b(5) Reductase/NADH System Efficiently Reduces Cytoglobins 1 and 2: Conserved Activity of Cytochrome b(5)/Cytochrome b(5) Reductases during Vertebrate Evolution. Amdahl MB, et al. Biochemistry, 2019 Jul 23. PMID 31257865, Free PMC Article
  3. Growth and Antioxidant-Related Effects of the Reestablished Ascorbic Acid Pathway in Zebrafish (Danio rerio) by Genomic Integration of L-Gulonolactone Oxidase From Cloudy Catshark (Scyliorhinus torazame). Shanaka KASN, et al. Front Physiol, 2021. PMID 34290620, Free PMC Article
  4. Retinoic acid receptor signaling regulates choroid fissure closure through independent mechanisms in the ventral optic cup and periocular mesenchyme. Lupo G, et al. Proc Natl Acad Sci U S A, 2011 May 24. PMID 21555593, Free PMC Article
  5. Zebrafish whole-adult-organism chemogenomics for large-scale predictive and discovery chemical biology. Lam SH, et al. PLoS Genet, 2008 Jul 11. PMID 18618001, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables heme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to xenobiotic stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome b5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213135.2 → NP_998300.2  cytochrome b5

    Status: VALIDATED

    Source sequence(s)
    BX784022
    UniProtKB/TrEMBL
    A0A8M2BA27, A8WGS0, Q7T341
    Related
    ENSDARP00000140832.1, ENSDART00000165290.2
    Conserved Domains (1) summary
    pfam00173
    Location:15 → 87
    Cyt-b5; Cytochrome b5-like Heme/Steroid binding domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    2836307..2843039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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