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arih2 ariadne homolog 2 (Drosophila) [ Danio rerio (zebrafish) ]

Gene ID: 406417, updated on 4-Jan-2025

Summary

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Official Symbol
arih2provided by ZNC
Official Full Name
ariadne homolog 2 (Drosophila)provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2158
See related
Ensembl:ENSDARG00000012848 AllianceGenome:ZFIN:ZDB-GENE-040426-2158
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:64093; wu:fa09c12
Summary
Predicted to enable ubiquitin conjugating enzyme binding activity and ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within protein ubiquitination. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See arih2 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (26034616..26057401)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (26015428..26038262)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene microRNA 135b Neighboring gene xeroderma pigmentosum, complementation group C Neighboring gene IMP (inosine 5'-monophosphate) dehydrogenase 2 Neighboring gene microRNA 462

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of amacrine subtypes that express the atypical cadherin celsr3. Lewis AA, et al. Exp Eye Res, 2015 Jan. PMID 25479044, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin conjugating enzyme binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase ARIH2
NP_998308.1
XP_009302263.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213143.1 → NP_998308.1  E3 ubiquitin-protein ligase ARIH2

    See identical proteins and their annotated locations for NP_998308.1

    Status: PROVISIONAL

    Source sequence(s)
    BC053248
    UniProtKB/TrEMBL
    A0A8M1PNX8, Q7T355
    Related
    ENSDARP00000011198.8, ENSDART00000004521.10
    Conserved Domains (2) summary
    smart00647
    Location:199 → 261
    IBR; In Between Ring fingers
    pfam01485
    Location:289 → 321
    IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    26034616..26057401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009303988.4 → XP_009302263.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    See identical proteins and their annotated locations for XP_009302263.1

    UniProtKB/TrEMBL
    A0A8M1PNX8, Q7T355
    Conserved Domains (2) summary
    smart00647
    Location:199 → 261
    IBR; In Between Ring fingers
    pfam01485
    Location:289 → 321
    IBR; IBR domain, a half RING-finger domain
Nucleotide Protein Strain
Heading Accession and Version

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