ddc dopa decarboxylase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ddcprovided by ZNC
Official Full Name: dopa decarboxylaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2656
See related: Ensembl:ENSDARG00000016494 AllianceGenome:ZFIN:ZDB-GENE-040426-2656
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:65801; zgc:76929; wu:fa56d05; wu:fd59h03; wu:fk20h01
Summary: Predicted to enable aromatic-L-amino-acid decarboxylase activity. Acts upstream of or within brain development. Predicted to be active in cytoplasm. Is expressed in digestive system; muscle; nervous system; ovary; and pharyngeal arch. Human ortholog(s) of this gene implicated in Parkinson's disease; aromatic L-amino acid decarboxylase deficiency; bipolar disorder; inherited metabolic disorder; and nicotine dependence. Orthologous to human DDC (dopa decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 16

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (8298542..8342749, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (8384813..8429020, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of Ddc appears to result in similar phenotypes as that of ADCC deficiency, thus zebrafish could be a good model for investigating pathogenetic mechanisms of AADC deficiency in children.
Title: Aromatic L-amino acid decarboxylase (AADC) is crucial for brain development and motor functions.

Submit: New GeneRIF Correction

General gene information

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Markers

fc23d08.x1 (e-PCR)
- UniSTS:193148

fc86d12.x1 (e-PCR)
- UniSTS:194684

fa56d05 (e-PCR)
- UniSTS:188821

fj85d03.x1 (e-PCR)
- UniSTS:200114

fd59h03.x1 (e-PCR)
- UniSTS:195772

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables aromatic-L-amino-acid decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables aromatic-L-amino-acid decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within amino acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within catecholamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in catecholamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in serotonin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: aromatic-L-amino-acid decarboxylase

Names: aromatic amino acid decarboxylase

NP_998507.1

EC 4.1.1.28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213342.1 → NP_998507.1 aromatic-L-amino-acid decarboxylase

See identical proteins and their annotated locations for NP_998507.1

Status: PROVISIONAL

Source sequence(s)

BC056292

UniProtKB/TrEMBL

Q6NVC7, Q7SZR0

Related

ENSDARP00000005382.7, ENSDART00000028108.8

Conserved Domains (1) summary

cl18945
Location:1 → 478

AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...