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pi4k2a phosphatidylinositol 4-kinase type 2 alpha [ Danio rerio (zebrafish) ]

Gene ID: 406667, updated on 17-Aug-2024

Summary

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Official Symbol
pi4k2aprovided by ZNC
Official Full Name
phosphatidylinositol 4-kinase type 2 alphaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2675
See related
Ensembl:ENSDARG00000033666 AllianceGenome:ZFIN:ZDB-GENE-040426-2675
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pi4kii; zgc:63646; wu:fc84f05; pi4kII alpha
Summary
Predicted to enable 1-phosphatidylinositol 4-kinase activity; AP-3 adaptor complex binding activity; and ATP binding activity. Predicted to be involved in Golgi organization; endosome organization; and phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within phosphorylation. Predicted to be located in several cellular components, including growing cell tip; membrane raft; and presynaptic membrane. Predicted to be integral component of plasma membrane. Predicted to be active in endosome; plasma membrane; and trans-Golgi network. Orthologous to human PI4K2A (phosphatidylinositol 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (54737406..54755556)
105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (54059755..54077905)

Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene phosphoglycerate mutase 1b Neighboring gene cell division cycle 25 homolog d Neighboring gene arginine vasopressin induced 1 Neighboring gene NLR family CARD domain containing 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Crucial role of phosphatidylinositol 4-kinase IIIalpha in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling. Ma H, et al. J Cell Sci, 2009 Dec 1. PMID 19887586, Free PMC Article
  2. Parental exposure to environmental concentrations of tris(1,3-dichloro-2-propyl)phosphate induces abnormal DNA methylation and behavioral changes in F1 zebrafish larvae. Ding X, et al. Environ Pollut, 2020 Dec. PMID 32841905
  3. Migratory Neural Crest Cells Phagocytose Dead Cells in the Developing Nervous System. Zhu Y, et al. Cell, 2019 Sep 19. PMID 31495570, Free PMC Article
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol 4-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol 4-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables AP-3 adaptor complex binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of BLOC-1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in growing cell tip ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane raft ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in presynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-kinase type 2-alpha
Names
PI4KII-alpha
phosphatidylinositol 4-kinase II alpha
phosphatidylinositol 4-kinase type II
phosphatidylinositol 4-kinase type II-alpha
NP_998523.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213358.2 → NP_998523.1  phosphatidylinositol 4-kinase type 2-alpha

    See identical proteins and their annotated locations for NP_998523.1

    Status: VALIDATED

    Source sequence(s)
    AL929041, BX119918
    UniProtKB/Swiss-Prot
    A5PF25, Q52PF3, Q6PE18
    Related
    ENSDARP00000112458.2, ENSDART00000130675.4
    Conserved Domains (2) summary
    PHA02777
    Location:20 → 87
    PHA02777; major capsid L1 protein; Provisional
    pfam00454
    Location:102 → 397
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007112.7 Reference GRCz11 Primary Assembly

    Range
    54737406..54755556
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PE18.1 GenPept UniProtKB/Swiss-Prot:Q6PE18

Gene LinkOut

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