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hnrnpdl heterogeneous nuclear ribonucleoprotein D-like [ Danio rerio (zebrafish) ]

Gene ID: 406701, updated on 12-Sep-2024

Summary

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Official Symbol
hnrnpdlprovided by ZNC
Official Full Name
heterogeneous nuclear ribonucleoprotein D-likeprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2717
See related
Ensembl:ENSDARG00000003429 AllianceGenome:ZFIN:ZDB-GENE-040426-2717
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hnrpdl; zgc:66169; wu:fa11d08
Summary
Predicted to enable poly(A) binding activity and poly(G) binding activity. Predicted to be involved in regulation of gene expression. Predicted to be located in cytoplasm and nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy type 3. Orthologous to human HNRNPDL (heterogeneous nuclear ribonucleoprotein D like). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 10
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (5017216..5024520, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (5016912..5024226, complement)

Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene si:ch73-234b20.5 Neighboring gene heterogeneous nuclear ribonucleoprotein D Neighboring gene enolase-phosphatase 1 Neighboring gene transmembrane protein 150C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A defect in the RNA-processing protein HNRPDL causes limb-girdle muscular dystrophy 1G (LGMD1G). Vieira NM, et al. Hum Mol Genet, 2014 Aug 1. PMID 24647604
  2. Proteomic analysis of methyl parathion-responsive proteins in zebrafish (Danio rerio) brain. Huang QY, et al. Comp Biochem Physiol C Toxicol Pharmacol, 2011 Jan. PMID 20826231
  3. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
  4. An evolutionary approach to recover genes predominantly expressed in the testes of the zebrafish, chicken and mouse. Fouchécourt S, et al. BMC Evol Biol, 2019 Jul 3. PMID 31269894, Free PMC Article
  5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(G) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
heterogeneous nuclear ribonucleoprotein D-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001328494.1 → NP_001315423.1  heterogeneous nuclear ribonucleoprotein D-like

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the protein.
    Source sequence(s)
    CR847788, EH541511, EH541767, EH562663, EH585301
    UniProtKB/TrEMBL
    A0A8M9QC13, Q7SXN2
    Related
    ENSDARP00000152490.1, ENSDART00000189017.1
    Conserved Domains (2) summary
    cd12585
    Location:116 → 190
    RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
    cd12758
    Location:31 → 106
    RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins

RNA

  1. NR_137312.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CR847788, EH585301

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007121.7 Reference GRCz11 Primary Assembly

    Range
    5017216..5024520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005155542.4 → XP_005155599.1  heterogeneous nuclear ribonucleoprotein D-like isoform X2

    See identical proteins and their annotated locations for XP_005155599.1

    UniProtKB/TrEMBL
    A0A8M9QKN0
    Conserved Domains (2) summary
    cd12585
    Location:116 → 190
    RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
    cd12758
    Location:31 → 106
    RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins

  2. XM_068223762.1 → XP_068079863.1  heterogeneous nuclear ribonucleoprotein D-like isoform X2

  3. XM_021479149.2 → XP_021334824.1  heterogeneous nuclear ribonucleoprotein D-like isoform X1

    UniProtKB/TrEMBL
    A0A8M9QC13, Q7SXN2
    Conserved Domains (2) summary
    cd12585
    Location:116 → 190
    RRM2_hnRPDL; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP DL) and similar proteins
    cd12758
    Location:31 → 106
    RRM1_hnRPDL; RNA recognition motif 1 in heterogeneous nuclear ribonucleoprotein D-like (hnRNP D-like or hnRNP DL) and similar proteins

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394763.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    71644..79249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395286.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    65127..72685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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