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nudt1 nudix (nucleoside diphosphate linked moiety X)-type motif 1 [ Danio rerio (zebrafish) ]

Gene ID: 406727, updated on 2-Nov-2024

Summary

Official Symbol
nudt1provided by ZNC
Official Full Name
nudix (nucleoside diphosphate linked moiety X)-type motif 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2757
See related
Ensembl:ENSDARG00000030573 AllianceGenome:ZFIN:ZDB-GENE-040426-2757
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mth1; zgc:56560; wu:fb40g09
Summary
Enables nucleoside triphosphate diphosphatase activity and phosphatase activity. Acts upstream of or within purine deoxyribonucleotide metabolic process. Predicted to be located in cytosol; mitochondrial matrix; and nucleus. Predicted to be active in cytoplasm. Orthologous to human NUDT1 (nudix hydrolase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See nudt1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (42121166..42125655, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (41979308..41983797, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene tweety family member 3a Neighboring gene sorting nexin 8a Neighboring gene mitochondrial rRNA methyltransferase 2 Neighboring gene zgc:194207

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in DNA protection IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within DNA protection IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within purine deoxyribonucleotide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
oxidized purine nucleoside triphosphate hydrolase
Names
2-hydroxy-dATP diphosphatase
7,8-dihydro-8-oxoguanine triphosphatase
8-oxo-dGTPase
methylated purine nucleoside triphosphate hydrolase
nucleoside diphosphate-linked moiety X motif 1
nudix motif 1
NP_998583.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_213418.1NP_998583.1  oxidized purine nucleoside triphosphate hydrolase

    See identical proteins and their annotated locations for NP_998583.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049486
    UniProtKB/Swiss-Prot
    Q7ZWC3
    Related
    ENSDARP00000040752.5, ENSDART00000040753.6
    Conserved Domains (1) summary
    cd03427
    Location:5140
    MTH1; MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    42121166..42125655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)