sesn3 sestrin 3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sesn3provided by ZNC
Official Full Name: sestrin 3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2924
See related: Ensembl:ENSDARG00000015822 AllianceGenome:ZFIN:ZDB-GENE-040426-2924
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb261; sb:cb261; zgc:56722; wu:fb77c04; wu:fc41d03; wu:fd59d12
Summary: Predicted to enable L-leucine binding activity and oxidoreductase activity, acting on peroxide as acceptor. Acts upstream of or within locomotory behavior. Predicted to be located in cytoplasm and nucleus. Is expressed in axis; brain; hypochord; and yolk syncytial layer. Orthologous to human SESN3 (sestrin 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 15

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	15	NC_007126.7 (35043009..35092735)
105	previous assembly	GRCz10 (GCF_000002035.5)	15	NC_007126.6 (35185040..35234766)

Chromosome 15 - NC_007126.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fb77c04.x1 (e-PCR)
- UniSTS:191349

fb77c04.x1 (e-PCR)
- UniSTS:191350

fe23c12.x1 (e-PCR)
- UniSTS:196294

fc41d03.x1 (e-PCR)
- UniSTS:188139

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables L-leucine binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on peroxide as acceptor	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to L-leucine	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to leucine starvation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of response to reactive oxygen species	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sestrin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.