nup133 nucleoporin 133 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nup133provided by ZNC
Official Full Name: nucleoporin 133provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2941
See related: Ensembl:ENSDARG00000010078 AllianceGenome:ZFIN:ZDB-GENE-040426-2941
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:55311; wu:fa04e09
Summary: Predicted to be a structural constituent of nuclear pore. Predicted to be involved in poly(A)+ mRNA export from nucleus; protein import into nucleus; and transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery. Predicted to act upstream of or within mRNA transport and protein transport. Predicted to be located in kinetochore and nucleus. Predicted to be part of nuclear pore outer ring. Is expressed in several structures, including heart; integument; liver; nervous system; and pleuroperitoneal region. Used to study Galloway-Mowat syndrome 1. Human ortholog(s) of this gene implicated in Galloway-Mowat syndrome and nephrotic syndrome type 18. Orthologous to human NUP133 (nucleoporin 133). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 1

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (53919110..53941906)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (53259367..53282163)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Moderate Nucleoporin 133 deficiency leads to glomerular damage in zebrafish.
Title: Moderate Nucleoporin 133 deficiency leads to glomerular damage in zebrafish.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of nuclear pore	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in poly(A)+ mRNA export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore outer ring	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: nuclear pore complex protein Nup133

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213531.1 → NP_998696.1 nuclear pore complex protein Nup133

See identical proteins and their annotated locations for NP_998696.1

Status: PROVISIONAL

Source sequence(s)

BC052764

UniProtKB/Swiss-Prot

F1QNV4, Q7SZE9

Related

ENSDARP00000023984.8, ENSDART00000020680.9

Conserved Domains (2) summary

pfam03177
Location:574 → 1061

Nucleoporin_C; Non-repetitive/WGA-negative nucleoporin C-terminal

pfam08801
Location:67 → 451

Nucleoporin_N; Nup133 N terminal like