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chchd3a coiled-coil-helix-coiled-coil-helix domain containing 3a [ Danio rerio (zebrafish) ]

Gene ID: 407730, updated on 4-Jan-2025

Summary

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Official Symbol
chchd3aprovided by ZNC
Official Full Name
coiled-coil-helix-coiled-coil-helix domain containing 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5005
See related
Ensembl:ENSDARG00000032919 AllianceGenome:ZFIN:ZDB-GENE-030131-5005
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
chchd3; mic19a; plxna4; wu:fe23h05; zgc:111837; si:rp71-18a24.1
Summary
Predicted to be located in membrane and mitochondrion. Predicted to be part of MICOS complex. Orthologous to human CHCHD3 (coiled-coil-helix-coiled-coil-helix domain containing 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See chchd3a in Genome Data Viewer
Location:
chromosome: 4
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (15490215..15603588, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (15491460..15604833, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene plexin A4 Neighboring gene uncharacterized LOC103910431 Neighboring gene uncharacterized LOC137491534 Neighboring gene exocyst complex component 4 Neighboring gene si:ch211-92l17.1 Neighboring gene uncharacterized LOC137491535

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish orthologue of the human hepatocerebral disease gene MPV17 plays pleiotropic roles in mitochondria. Martorano L, et al. Dis Model Mech, 2019 Mar 14. PMID 30833296, Free PMC Article
  2. Functional visualization and disruption of targeted genes using CRISPR/Cas9-mediated eGFP reporter integration in zebrafish. Ota S, et al. Sci Rep, 2016 Oct 11. PMID 27725766, Free PMC Article
  3. Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome. Huang M, et al. Nat Commun, 2022 Oct 5. PMID 36198703, Free PMC Article
  4. Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. Burkhalter MD, et al. J Clin Invest, 2019 May 16. PMID 31094706, Free PMC Article
  5. Functional analysis of human hematopoietic stem cell gene expression using zebrafish. Eckfeldt CE, et al. PLoS Biol, 2005 Aug. PMID 16089502, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • FLJ20420

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
part_of MICOS complex IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coiled-coil-helix-coiled-coil-helix domain containing 3a
Names
coiled-coil-helix-coiled-coil-helix domain containing 3
plexin A4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001309796.1 → NP_001296725.1  coiled-coil-helix-coiled-coil-helix domain containing 3a isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    BX649386, BX649446
    UniProtKB/TrEMBL
    A0A0R4IUL1, A0A8M1P7S4
    Related
    ENSDARP00000139417.2, ENSDART00000162356.2
    Conserved Domains (1) summary
    pfam05300
    Location:15 → 260
    DUF737; Protein of unknown function (DUF737)

  2. NM_214804.2 → NP_999969.2  coiled-coil-helix-coiled-coil-helix domain containing 3a isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BX649386, BX649446
    UniProtKB/TrEMBL
    A0A8M1PRC5, A0A8M9Q0D0, E7FFW8, Q5RH04
    Related
    ENSDARP00000105322.2, ENSDART00000122520.4
    Conserved Domains (1) summary
    pfam05300
    Location:15 → 265
    DUF737; Protein of unknown function (DUF737)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    15490215..15603588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009300263.4 → XP_009298538.1  coiled-coil-helix-coiled-coil-helix domain containing 3a isoform X2

    UniProtKB/TrEMBL
    A0A8M3ARL8, A0A8M3B1Q0
    Conserved Domains (1) summary
    pfam05300
    Location:209 → 372
    DUF737; Protein of unknown function (DUF737)

  2. XM_009300261.4 → XP_009298536.1  coiled-coil-helix-coiled-coil-helix domain containing 3a isoform X1

    UniProtKB/TrEMBL
    A0A8M3ARL8, A0A8M3B8X9
    Conserved Domains (1) summary
    pfam05300
    Location:209 → 377
    DUF737; Protein of unknown function (DUF737)
Nucleotide Protein Strain
Heading Accession and Version

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