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pnn pinin, desmosome associated protein [ Danio rerio (zebrafish) ]

Gene ID: 407733, updated on 2-Nov-2024

Summary

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Official Symbol
pnnprovided by ZNC
Official Full Name
pinin, desmosome associated proteinprovided by ZNC
Primary source
ZFIN:ZDB-GENE-060519-3
See related
Ensembl:ENSDARG00000015851 AllianceGenome:ZFIN:ZDB-GENE-060519-3
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fb24d03; wu:fb24d03
Summary
Predicted to enable DNA binding activity. Acts upstream of or within neural crest cell differentiation. Predicted to be located in desmosome and nuclear speck. Predicted to be part of catalytic step 2 spliceosome. Orthologous to human PNN (pinin, desmosome associated protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See pnn in Genome Data Viewer
Location:
chromosome: 17
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (13099476..13110122)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (13089052..13099704)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene MIA SH3 domain ER export factor 2 Neighboring gene gem (nuclear organelle) associated protein 2 Neighboring gene transfer RNA leucine (anticodon UAA) Neighboring gene uncharacterized LOC137488076

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Dissection of the role of Pinin in the development of zebrafish posterior pharyngeal cartilages. Hsu SY, et al. Histochem Cell Biol, 2012 Jul. PMID 22527695
  2. The earliest transcribed zygotic genes are short, newly evolved, and different across species. Heyn P, et al. Cell Rep, 2014 Jan 30. PMID 24440719
  3. Processing of fish Ig heavy chain transcripts: diverse splicing patterns and unusual nonsense mediated decay. Quiniou SM, et al. Dev Comp Immunol, 2011 Sep. PMID 21168434
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neural crest cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in desmosome IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
pinin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172570.1 → NP_001166041.1  pinin

    Status: VALIDATED

    Source sequence(s)
    AW203111, BC081665, BM102167, EB835206
    UniProtKB/TrEMBL
    A0A8M1NUL0, F1QT45, Q66HU9
    Related
    ENSDARP00000011002.5, ENSDART00000012670.7
    Conserved Domains (2) summary
    pfam04696
    Location:137 → 262
    Pinin_SDK_memA; pinin/SDK/memA/ protein conserved region
    pfam04697
    Location:5 → 133
    Pinin_SDK_N; pinin/SDK conserved region

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    13099476..13110122
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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