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CG2747 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 40950, updated on 4-Jan-2025

Summary

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Official Symbol
CG2747provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0037541
Locus tag
Dmel_CG2747
See related
AllianceGenome:FB:FBgn0037541
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG2747
Summary
Enables molecular adaptor activity. Involved in retrograde transport, endosome to Golgi. Predicted to be active in endocytic vesicle. Is expressed in adult head; larval ventral nerve cord; organism; and ventral nerve cord primordium. Orthologous to human HEATR5A (HEAT repeat containing 5A) and HEATR5B (HEAT repeat containing 5B). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See CG2747 in Genome Data Viewer
Location:
84E8-84E9; 3-48 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8016210..8030790, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3841932..3856512, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene PSEA-binding protein 95kD Neighboring gene Ecdysone-inducible gene E3 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncoordinated 45

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comparative genomic analyses reveal evidence for adaptive A-to-I RNA editing in insect Adar gene. Zheng C, et al. Epigenetics, 2024 Dec. PMID 38525798, Free PMC Article
  2. HEATR5B associates with dynein-dynactin and promotes motility of AP1-bound endosomal membranes. Madan V, et al. EMBO J, 2023 Dec 1. PMID 37872872, Free PMC Article
  3. Regulation of Drosophila eye development by the transcription factor Sine oculis. Jusiak B, et al. PLoS One, 2014. PMID 24586968, Free PMC Article
  4. Musashi expression in intestinal stem cells attenuates radiation-induced decline in intestinal permeability and survival in Drosophila. Sharma A, et al. Sci Rep, 2020 Nov 5. PMID 33154387, Free PMC Article
  5. Fractionation profiling: a fast and versatile approach for mapping vesicle proteomes and protein-protein interactions. Borner GH, et al. Mol Biol Cell, 2014 Oct 15. PMID 25165137, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde transport, endosome to Golgi IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG2747-PA
CG2747-PB
CG2747-PC
CG2747-PD
CG2747-PE
CG2747-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    8016210..8030790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170077.2 → NP_001163548.1  uncharacterized protein Dmel_CG2747, isoform D [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q32KD3
    Conserved Domains (1) summary
    sd00044
    Location:97 → 125
    HEAT; HEAT repeat [structural motif]

  2. NM_169205.3 → NP_731206.1  uncharacterized protein Dmel_CG2747, isoform B [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KSW1
    Related
    FBpp0081307
    Conserved Domains (1) summary
    sd00044
    Location:97 → 125
    HEAT; HEAT repeat [structural motif]

  3. NM_001275434.1 → NP_001262363.1  uncharacterized protein Dmel_CG2747, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGS8
    Conserved Domains (1) summary
    sd00044
    Location:145 → 173
    HEAT; HEAT repeat [structural motif]

  4. NM_001275435.1 → NP_001262364.1  uncharacterized protein Dmel_CG2747, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KGF6
    Conserved Domains (1) summary
    sd00044
    Location:145 → 173
    HEAT; HEAT repeat [structural motif]

  5. NM_001170076.2 → NP_001163547.1  uncharacterized protein Dmel_CG2747, isoform C [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q494I1
    Conserved Domains (1) summary
    sd00044
    Location:145 → 173
    HEAT; HEAT repeat [structural motif]

  6. NM_141504.3 → NP_649761.2  uncharacterized protein Dmel_CG2747, isoform A [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VHW9
    Related
    FBpp0081308
    Conserved Domains (1) summary
    sd00044
    Location:145 → 173
    HEAT; HEAT repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KGF6 A0A0B4KGF6
A0A0B4KGS8 A0A0B4KGS8
Q32KD3 Q32KD3
Q494I1 Q494I1
Q7KSW1 Q7KSW1
Q9VHW9 Q9VHW9

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