U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cops2 COP9 signalosome subunit 2 [ Danio rerio (zebrafish) ]

Gene ID: 415145, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
cops2provided by ZNC
Official Full Name
COP9 signalosome subunit 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-15
See related
Ensembl:ENSDARG00000004785 AllianceGenome:ZFIN:ZDB-GENE-040625-15
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86624; wu:fc05f05; wu:fc06g10; wu:fc60f04; wu:fl94f12
Summary
Predicted to be involved in negative regulation of nucleic acid-templated transcription and protein deneddylation. Predicted to be located in nucleus. Predicted to be part of COP9 signalosome. Orthologous to human COPS2 (COP9 signalosome subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cops2 in Genome Data Viewer
Location:
chromosome: 25
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (32366064..32381629, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (31955102..31970706, complement)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 27 member 2b Neighboring gene centrosomal protein 152 Neighboring gene uncharacterized LOC103909877 Neighboring gene uncharacterized LOC101882990

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Deletion of a conserved Gata2 enhancer impairs haemogenic endothelium programming and adult Zebrafish haematopoiesis. Dobrzycki T, et al. Commun Biol, 2020 Feb 13. PMID 32054973, Free PMC Article
  2. Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression. Bertrand S, et al. PLoS Genet, 2007 Nov. PMID 17997606, Free PMC Article
  3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein deneddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
COP9 signalosome complex subunit 2
Names
Alien
COP9 constitutive photomorphogenic homolog subunit 2
signalosome subunit 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002055.1 → NP_001002055.1  COP9 signalosome complex subunit 2

    See identical proteins and their annotated locations for NP_001002055.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071320
    UniProtKB/Swiss-Prot
    Q6IQT4
    Related
    ENSDARP00000012359.5, ENSDART00000006124.8
    Conserved Domains (2) summary
    COG5159
    Location:40 → 441
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:309 → 413
    PCI; PCI domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    32366064..32381629 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470471.2 → XP_021326146.1  COP9 signalosome complex subunit 2 isoform X2

    UniProtKB/TrEMBL
    A0A8M9PUW2
    Conserved Domains (2) summary
    COG5159
    Location:164 → 411
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:279 → 383
    PCI; PCI domain

  2. XM_005163159.5 → XP_005163216.1  COP9 signalosome complex subunit 2 isoform X1

    UniProtKB/TrEMBL
    A0A8M2BAA6
    Conserved Domains (3) summary
    COG5159
    Location:40 → 443
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:311 → 415
    PCI; PCI domain
    pfam12018
    Location:86 → 220
    DUF3508; Domain of unknown function (DUF3508)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IQT4.1 GenPept UniProtKB/Swiss-Prot:Q6IQT4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous