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ppid peptidylprolyl isomerase D [ Danio rerio (zebrafish) ]

Gene ID: 415155, updated on 2-Nov-2024

Summary

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Official Symbol
ppidprovided by ZNC
Official Full Name
peptidylprolyl isomerase Dprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-34
See related
Ensembl:ENSDARG00000038835 AllianceGenome:ZFIN:ZDB-GENE-040625-34
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86711; wu:fb18b07
Summary
Predicted to enable cyclosporin A binding activity and peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Predicted to act upstream of or within protein peptidyl-prolyl isomerization. Predicted to be active in cytosol. Orthologous to human PPID (peptidylprolyl isomerase D). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See ppid in Genome Data Viewer
Location:
chromosome: 14
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (48045193..48065365)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (49056540..49077608)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor 2b Neighboring gene transfer RNA glutamine (anticodon CUG) Neighboring gene sperm microtubule inner protein 2 Neighboring gene electron transfer flavoprotein dehydrogenase Neighboring gene relaxin family peptide receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Roca FJ, et al. Cell, 2013 Apr 25. PMID 23582643, Free PMC Article
  2. TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit. Roca FJ, et al. Cell, 2019 Sep 5. PMID 31474371, Free PMC Article
  3. The proteomic study on cellular responses of the testes of zebrafish (Danio rerio) exposed to microcystin-RR. Zhao S, et al. Proteomics, 2012 Jan. PMID 22140076
  4. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein folding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase D
NP_001002065.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002065.1 → NP_001002065.1  peptidyl-prolyl cis-trans isomerase D

    See identical proteins and their annotated locations for NP_001002065.1

    Status: PROVISIONAL

    Source sequence(s)
    BC071388
    UniProtKB/TrEMBL
    A0A8M1MZT4, F1R5R3, Q6IQL7
    Related
    ENSDARP00000107677.2, ENSDART00000124773.4
    Conserved Domains (5) summary
    cd01926
    Location:16 → 182
    cyclophilin_ABH_like; cyclophilin_ABH_like: Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which ...
    sd00006
    Location:223 → 268
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:309 → 341
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:223 → 304
    TPR_11; TPR repeat
    pfam13424
    Location:271 → 340
    TPR_12; Tetratricopeptide repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    48045193..48065365
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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