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msrb3 methionine sulfoxide reductase B3 [ Danio rerio (zebrafish) ]

Gene ID: 415184, updated on 2-Nov-2024

Summary

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Official Symbol
msrb3provided by ZNC
Official Full Name
methionine sulfoxide reductase B3provided by ZNC
Primary source
ZFIN:ZDB-GENE-040625-74
See related
Ensembl:ENSDARG00000045658 AllianceGenome:ZFIN:ZDB-GENE-040625-74
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:86909; wu:fc07g04
Summary
Predicted to enable peptide-methionine (R)-S-oxide reductase activity. Acts upstream of or within inner ear development. Predicted to be active in cytoplasm. Is expressed in heart rudiment; heart tube; inner ear; and myotome. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 74. Orthologous to human MSRB3 (methionine sulfoxide reductase B3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See msrb3 in Genome Data Viewer
Location:
chromosome: 4
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (12892467..12914192, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (12893618..12915343, complement)

Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene high mobility group AT-hook 2 Neighboring gene uncharacterized LOC103910419 Neighboring gene LEM domain containing 3 Neighboring gene wnt inhibitory factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish. Shen X, et al. Int J Dev Biol, 2015. PMID 26505252
  2. Porcine methionine sulfoxide reductase B3: molecular cloning, tissue-specific expression profiles, and polymorphisms associated with ear size in Sus scrofa. Zhang Y, et al. J Anim Sci Biotechnol, 2015. PMID 26719797, Free PMC Article
  3. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. Manchenkov T, et al. G3 (Bethesda), 2015 Apr 3. PMID 25840431, Free PMC Article
  4. Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells. Gavriouchkina D, et al. PLoS One, 2010 Sep 7. PMID 20830285, Free PMC Article
  5. Zebrafish peptidoglycan recognition protein SC (zfPGRP-SC) mediates multiple intracellular signaling pathways. Chang MX, et al. Fish Shellfish Immunol, 2009 Feb. PMID 19084604

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that methionine sulfoxide reductase B3 (msrb3) is instrumental for auditory system development in zebrafish.
    Title: Down-regulation of msrb3 and destruction of normal auditory system development through hair cell apoptosis in zebrafish.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-methionine (R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inner ear development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methionine-R-sulfoxide reductase B3
NP_001002094.2
NP_001307307.1
NP_001307309.1
XP_009298392.1
XP_068075682.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002094.2 → NP_001002094.2  methionine-R-sulfoxide reductase B3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon in the 5' UTR and 5' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BX119963
    UniProtKB/TrEMBL
    A0A8M1MZV0, Q5TZH6, Q5TZH7
    Related
    ENSDARP00000120380.1, ENSDART00000145917.3
    Conserved Domains (1) summary
    PRK00222
    Location:35 → 168
    PRK00222; methionine sulfoxide reductase B; Provisional

  2. NM_001320378.1 → NP_001307307.1  methionine-R-sulfoxide reductase B3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BX119963
    UniProtKB/TrEMBL
    A0A8M1P8M4, F6P046
    Related
    ENSDARP00000122154.1, ENSDART00000140002.3
    Conserved Domains (1) summary
    PRK00222
    Location:49 → 182
    PRK00222; methionine sulfoxide reductase B; Provisional

  3. NM_001320380.1 → NP_001307309.1  methionine-R-sulfoxide reductase B3 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR and 5' coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    BX119963
    UniProtKB/TrEMBL
    A0A8M1P7N2, Q5TZH8
    Related
    ENSDARP00000123270.2, ENSDART00000141355.3
    Conserved Domains (1) summary
    PRK00222
    Location:36 → 169
    PRK00222; methionine sulfoxide reductase B; Provisional

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007115.7 Reference GRCz11 Primary Assembly

    Range
    12892467..12914192 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009300117.3 → XP_009298392.1  methionine-R-sulfoxide reductase B3 isoform X1

    See identical proteins and their annotated locations for XP_009298392.1

    UniProtKB/TrEMBL
    A0A8M1P8M4, F6P046
    Conserved Domains (1) summary
    PRK00222
    Location:49 → 182
    PRK00222; methionine sulfoxide reductase B; Provisional

  2. XM_068219581.1 → XP_068075682.1  methionine-R-sulfoxide reductase B3 isoform X2

    Related
    ENSDARP00000067134.3, ENSDART00000067135.4
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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