eaf2 ELL associated factor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eaf2provided by ZNC
Official Full Name: ELL associated factor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-179
See related: Ensembl:ENSDARG00000010432 AllianceGenome:ZFIN:ZDB-GENE-040625-179
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:86600; wu:fb76c01; wu:fc43g12
Summary: Enables armadillo repeat domain binding activity; beta-catenin binding activity; and transcription corepressor activity. Acts upstream of or within several processes, including cell migration involved in gastrulation; convergent extension; and transforming growth factor beta receptor signaling pathway. Predicted to be located in nucleus. Predicted to be part of transcription elongation factor complex. Is expressed in several structures, including blastoderm; blastodisc; nervous system; pleuroperitoneal region; and presumptive neural retina. Orthologous to human EAF2 (ELL associated factor 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	9	NC_007120.7 (23003208..23007941)
105	previous assembly	GRCz10 (GCF_000002035.5)	9	NC_007120.6 (23192339..23197072)

Chromosome 9 - NC_007120.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Eaf1 and Eaf2 mediate zebrafish dorsal-ventral axis patterning via suppressing Wnt/beta-Catenin activity.
Title: Eaf1 and Eaf2 mediate zebrafish dorsal-ventral axis patterning via suppressing Wnt/β-Catenin activity.
study unveiled a previously unrecognized link of Eaf1/2 genes with TGF-beta and P53 in vertebrates and demonstrated a conservation of TGF-beta suppression activity for Eaf1/2 family genes from fish to mammals, which might shed some light on the molecular mechanistic basis of Eaf1 and Eaf2 in tumor suppression.
Title: Transcriptional factors Eaf1/2 inhibit endoderm and mesoderm formation via suppressing TGF-β signaling.
A novel role for Eaf1 and Eaf2 in inhibiting canonical Wnt/beta-catenin signaling, which might form the mechanistic basis for Eaf1 and Eaf2 tumor suppressor activity.
Title: Eaf1 and Eaf2 negatively regulate canonical Wnt/β-catenin signaling.
Findings provide the first convincing line of evidence that EAF and Wnt4 form an auto-regulatory negative feedback loop in vivo.
Title: Negative feedback regulation of Wnt4 signaling by EAF1 and EAF2/U19.
eaf1 and eaf2/u19 act upstream of noncanonical Wnt signaling to mediate convergence and extension movements
Title: Zebrafish eaf1 and eaf2/u19 mediate effective convergence and extension movements through the maintenance of wnt11 and wnt5 expression.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
enables transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription corepressor activity	IPI Inferred from Physical Interaction more info	PubMed
enables transcription elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within convergent extension involved in axis elongation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in organogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscle cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in transcription elongation by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of super elongation complex	IEA Inferred from Electronic Annotation more info
part_of transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ELL-associated factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.