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CG42788 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 41817, updated on 27-Dec-2024

Summary

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Official Symbol
CG42788provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0261859
Locus tag
Dmel_CG42788
See related
AllianceGenome:FB:FBgn0261859
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.79; CG18442; CG31304; CG6934; CG6960; Dmel\CG42788
Old locus tag
Dmel_CG31304; Dmel_CG6934
Summary
Predicted to be involved in signal transduction. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; head mesoderm; larval muscle system; somatic trunk mesoderm derivative; and trunk mesoderm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 104. Orthologous to several human genes including FRMPD4 (FERM and PDZ domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs
all
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Genomic context

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See CG42788 in Genome Data Viewer
Location:
88E1-88E2; 3-56 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15095957..15131926, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10921679..10957648, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-2493 stem loop Neighboring gene antisense RNA:CR45600 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Shadow Enhancers Are Pervasive Features of Developmental Regulatory Networks. Cannavò E, et al. Curr Biol, 2016 Jan 11. PMID 26687625, Free PMC Article
  2. Regulatory regions in natural transposable element insertions drive interindividual differences in response to immune challenges in Drosophila. Ullastres A, et al. Genome Biol, 2021 Sep 14. PMID 34521452, Free PMC Article
  3. Enhancer redundancy in development and disease. Kvon EZ, et al. Nat Rev Genet, 2021 May. PMID 33442000, Free PMC Article
  4. Parallel and population-specific gene regulatory evolution in cold-adapted fly populations. Huang Y, et al. Genetics, 2021 Jul 14. PMID 33989401, Free PMC Article
  5. Nuclear receptor DHR4 controls the timing of steroid hormone pulses during Drosophila development. Ou Q, et al. PLoS Biol, 2011 Sep. PMID 21980261, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c15109750-15102553 mobile_element_type = transposon:412{}1365

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG42788-PB
CG42788-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15095957..15131926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202293.3 → NP_001189222.1  uncharacterized protein Dmel_CG42788, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189222.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDC8
    Conserved Domains (7) summary
    smart00295
    Location:396 → 617
    B41; Band 4.1 homologues
    cd00201
    Location:218 → 246
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:257 → 333
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00373
    Location:495 → 617
    FERM_M; FERM central domain
    pfam00397
    Location:177 → 203
    WW; WW domain
    cl00155
    Location:396 → 477
    UBQ; Ubiquitin-like proteins
    cl17171
    Location:613 → 714
    PH-like; Pleckstrin homology-like domain

  2. NM_169609.4 → NP_731964.2  uncharacterized protein Dmel_CG42788, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731964.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VFD3
    Conserved Domains (7) summary
    smart00295
    Location:396 → 617
    B41; Band 4.1 homologues
    cd00201
    Location:218 → 246
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    cd00992
    Location:257 → 333
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00373
    Location:495 → 617
    FERM_M; FERM central domain
    pfam00397
    Location:177 → 203
    WW; WW domain
    cl00155
    Location:396 → 477
    UBQ; Ubiquitin-like proteins
    cl17171
    Location:613 → 715
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JDC8 A0A0B4JDC8
Q9VFD3 Q9VFD3

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