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ART3 ADP-ribosyltransferase 3 (inactive) [ Homo sapiens (human) ]

Gene ID: 419, updated on 2-Nov-2024

Summary

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Official Symbol
ART3provided by HGNC
Official Full Name
ADP-ribosyltransferase 3 (inactive)provided by HGNC
Primary source
HGNC:HGNC:725
See related
Ensembl:ENSG00000156219 MIM:603086; AllianceGenome:HGNC:725
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARTC3
Summary
This gene encodes an arginine-specific ADP-ribosyltransferase. The encoded protein catalyzes a reversible reaction which modifies proteins by the addition or removal of ADP-ribose to an arginine residue to regulate the function of the modified protein. An ADP-ribosyltransferase pseudogene is located on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Biased expression in testis (RPKM 18.7) and heart (RPKM 6.2) See more
Orthologs
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Genomic context

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See ART3 in Genome Data Viewer
Location:
4q21.1; 4p15.1-p14
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (76011190..76112786)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (79351693..79453452)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (76932343..77033939)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene SDA1 domain containing 1 Neighboring gene SDAD1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:76932273-76932917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21625 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:76938237-76938736 Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene C-X-C motif chemokine ligand 10 Neighboring gene ribosomal protein L36 pseudogene 8 Neighboring gene C-X-C motif chemokine ligand 11 Neighboring gene NANOG hESC enhancer GRCh37_chr4:77016693-77017194 Neighboring gene nucleoporin 54 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21626 Neighboring gene uncharacterized LOC124900718 Neighboring gene NANOG hESC enhancer GRCh37_chr4:77075501-77076330 Neighboring gene scavenger receptor class B member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways. Tan L, et al. Oncotarget, 2016 Jul 19. PMID 27374177, Free PMC Article
  2. Selective expression of RT6 superfamily in human bronchial epithelial cells. Balducci E, et al. Am J Respir Cell Mol Biol, 1999 Sep. PMID 10460751
  3. Mono-ADP-ribosyltransferases in human monocytes: regulation by lipopolysaccharide. Grahnert A, et al. Biochem J, 2002 Mar 15. PMID 11879200, Free PMC Article
  4. Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes. Friedrich M, et al. Asian J Androl, 2006 May. PMID 16625277
  5. Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility. Okada H, et al. PLoS Genet, 2008 Feb. PMID 18266473, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. knockdown of ART3 in breast cancer cells inhibited cell proliferation and invasion.
    Title: ART3 regulates triple-negative breast cancer cell function via activation of Akt and ERK pathways.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. genome-wide gene expression analyses were used to identify genes involved in the pathogenesis of non-obstructive azoospermia, and ART3 was subsequently identified as a susceptibility gene
    Title: Genome-wide expression of azoospermia testes demonstrates a specific profile and implicates ART3 in genetic susceptibility.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  6. ART3 protein is expressed in testes in particular on spermatocytes, indicating that ART3 exerts a specific function only required at a particular stage of spermatogenesis.
    Title: Expression of toxin-related human mono-ADP-ribosyltransferase 3 in human testes.
  7. ART3 expression appears to be governed by a combination of differential splicing and tissue-preferential use of two alternative promoters.
    Title: Genomic organization and expression of the human mono-ADP-ribosyltransferase ART3 gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26404

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ecto-ADP-ribosyltransferase 3
Names
ADP-ribosyltransferase C2 and C3 toxin-like 3
NAD(P)(+)--arginine ADP-ribosyltransferase 3
mono(ADP-ribosyl)transferase 3
mono-ADP-ribosyltransferase
NP_001123488.1
NP_001123489.1
NP_001170.2
NP_001364102.1
NP_001364103.1
NP_001364104.1
NP_001364105.1
NP_001364106.1
NP_001364107.1
NP_001364108.1
NP_001364109.1
NP_001364110.1
NP_001364111.1
NP_001364112.1
NP_001364113.1
NP_001364114.1
XP_016863695.1
XP_024309818.1
XP_024309819.1
XP_024309820.1
XP_024309821.1
XP_024309822.1
XP_024309824.1
XP_024309826.1
XP_024309827.1
XP_024309829.1
XP_024309830.1
XP_024309831.1
XP_047271651.1
XP_047271652.1
XP_047271653.1
XP_047271654.1
XP_047271655.1
XP_047271656.1
XP_054206006.1
XP_054206007.1
XP_054206008.1
XP_054206009.1
XP_054206010.1
XP_054206011.1
XP_054206012.1
XP_054206013.1
XP_054206014.1
XP_054206015.1
XP_054206016.1
XP_054206017.1
XP_054206018.1
XP_054206019.1
XP_054206020.1
XP_054206021.1
XP_054206022.1
XP_054206023.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130016.3 → NP_001123488.1  ecto-ADP-ribosyltransferase 3 isoform a precursor

    See identical proteins and their annotated locations for NP_001123488.1

    Status: VALIDATED

    Source sequence(s)
    AC112719
    Consensus CDS
    CCDS47079.1
    UniProtKB/Swiss-Prot
    Q13508, Q53XW3, Q6FHT7, Q8WVJ7, Q93069, Q96HL1
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Related
    ENSP00000348064.4, ENST00000355810.9
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  2. NM_001130017.3 → NP_001123489.1  ecto-ADP-ribosyltransferase 3 isoform c precursor

    See identical proteins and their annotated locations for NP_001123489.1

    Status: VALIDATED

    Source sequence(s)
    AC112719
    Consensus CDS
    CCDS47080.1
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Related
    ENSP00000343843.5, ENST00000341029.9
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  3. NM_001179.6 → NP_001170.2  ecto-ADP-ribosyltransferase 3 isoform b precursor

    See identical proteins and their annotated locations for NP_001170.2

    Status: VALIDATED

    Source sequence(s)
    AC112719
    Consensus CDS
    CCDS3575.1
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Related
    ENSP00000304313.5, ENST00000349321.7
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  4. NM_001377173.1 → NP_001364102.1  ecto-ADP-ribosyltransferase 3 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    Consensus CDS
    CCDS93546.1
    UniProtKB/TrEMBL
    H0Y8V6
    Related
    ENSP00000422249.2, ENST00000511188.2
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  5. NM_001377174.1 → NP_001364103.1  ecto-ADP-ribosyltransferase 3 isoform l precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  6. NM_001377175.1 → NP_001364104.1  ecto-ADP-ribosyltransferase 3 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    Consensus CDS
    CCDS47080.1
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  7. NM_001377176.1 → NP_001364105.1  ecto-ADP-ribosyltransferase 3 isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  8. NM_001377177.1 → NP_001364106.1  ecto-ADP-ribosyltransferase 3 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  9. NM_001377178.1 → NP_001364107.1  ecto-ADP-ribosyltransferase 3 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  10. NM_001377179.1 → NP_001364108.1  ecto-ADP-ribosyltransferase 3 isoform g precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  11. NM_001377180.1 → NP_001364109.1  ecto-ADP-ribosyltransferase 3 isoform h precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  12. NM_001377181.1 → NP_001364110.1  ecto-ADP-ribosyltransferase 3 isoform i precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  13. NM_001377182.1 → NP_001364111.1  ecto-ADP-ribosyltransferase 3 isoform i precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  14. NM_001377183.1 → NP_001364112.1  ecto-ADP-ribosyltransferase 3 isoform j precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  15. NM_001377184.1 → NP_001364113.1  ecto-ADP-ribosyltransferase 3 isoform j precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  16. NM_001377185.1 → NP_001364114.1  ecto-ADP-ribosyltransferase 3 isoform k precursor

    Status: VALIDATED

    Source sequence(s)
    AC112719
    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    76011190..76112786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047415697.1 → XP_047271653.1  ecto-ADP-ribosyltransferase 3 isoform X7

  2. XM_047415700.1 → XP_047271656.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7

  3. XM_047415695.1 → XP_047271651.1  ecto-ADP-ribosyltransferase 3 isoform X4

  4. XM_047415696.1 → XP_047271652.1  ecto-ADP-ribosyltransferase 3 isoform X7

  5. XM_047415699.1 → XP_047271655.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7

  6. XM_047415698.1 → XP_047271654.1  ecto-ADP-ribosyltransferase 3 isoform X7

  7. XM_024454063.2 → XP_024309831.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7, A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  8. XM_024454053.2 → XP_024309821.1  ecto-ADP-ribosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  9. XM_024454052.2 → XP_024309820.1  ecto-ADP-ribosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  10. XM_017008206.3 → XP_016863695.1  ecto-ADP-ribosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  11. XM_024454051.2 → XP_024309819.1  ecto-ADP-ribosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  12. XM_024454062.2 → XP_024309830.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7, A0A8V8TQ78
    Related
    ENSP00000514989.1, ENST00000700440.1
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  13. XM_024454056.2 → XP_024309824.1  ecto-ADP-ribosyltransferase 3 isoform X3

    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  14. XM_024454058.2 → XP_024309826.1  ecto-ADP-ribosyltransferase 3 isoform X5

    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  15. XM_024454059.2 → XP_024309827.1  ecto-ADP-ribosyltransferase 3 isoform X6

    UniProtKB/TrEMBL
    A0A8V8TQ78
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  16. XM_024454061.2 → XP_024309829.1  ecto-ADP-ribosyltransferase 3 isoform X8

    UniProtKB/TrEMBL
    A0A8V8TQ78
    Related
    ENSP00000514990.1, ENST00000700441.1
    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  17. XM_024454050.2 → XP_024309818.1  ecto-ADP-ribosyltransferase 3 isoform X1

    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

  18. XM_024454054.2 → XP_024309822.1  ecto-ADP-ribosyltransferase 3 isoform X2

    Conserved Domains (1) summary
    pfam01129
    Location:29 → 252
    ART; NAD:arginine ADP-ribosyltransferase

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    79351693..79453452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054350042.1 → XP_054206017.1  ecto-ADP-ribosyltransferase 3 isoform X7

  2. XM_054350047.1 → XP_054206022.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7

  3. XM_054350038.1 → XP_054206013.1  ecto-ADP-ribosyltransferase 3 isoform X4

  4. XM_054350041.1 → XP_054206016.1  ecto-ADP-ribosyltransferase 3 isoform X7

  5. XM_054350046.1 → XP_054206021.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7

  6. XM_054350043.1 → XP_054206018.1  ecto-ADP-ribosyltransferase 3 isoform X7

  7. XM_054350048.1 → XP_054206023.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7

  8. XM_054350035.1 → XP_054206010.1  ecto-ADP-ribosyltransferase 3 isoform X1

  9. XM_054350032.1 → XP_054206007.1  ecto-ADP-ribosyltransferase 3 isoform X1

  10. XM_054350033.1 → XP_054206008.1  ecto-ADP-ribosyltransferase 3 isoform X1

  11. XM_054350031.1 → XP_054206006.1  ecto-ADP-ribosyltransferase 3 isoform X1

  12. XM_054350045.1 → XP_054206020.1  ecto-ADP-ribosyltransferase 3 isoform X9

    UniProtKB/TrEMBL
    A0A8V8TPP7

  13. XM_054350037.1 → XP_054206012.1  ecto-ADP-ribosyltransferase 3 isoform X3

  14. XM_054350039.1 → XP_054206014.1  ecto-ADP-ribosyltransferase 3 isoform X5

  15. XM_054350040.1 → XP_054206015.1  ecto-ADP-ribosyltransferase 3 isoform X6

  16. XM_054350044.1 → XP_054206019.1  ecto-ADP-ribosyltransferase 3 isoform X8

  17. XM_054350034.1 → XP_054206009.1  ecto-ADP-ribosyltransferase 3 isoform X1

  18. XM_054350036.1 → XP_054206011.1  ecto-ADP-ribosyltransferase 3 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13508.2 GenPept UniProtKB/Swiss-Prot:Q13508

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