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CG31121 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 42975, updated on 22-Aug-2024

Summary

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Official Symbol
CG31121provided by FlyBase
Primary source
FLYBASE:FBgn0051121
Locus tag
Dmel_CG31121
See related
AllianceGenome:FB:FBgn0051121
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH19411; CG11764; CG18633; CG18655; DmCG31121; Dmel\CG31121
Summary
Predicted to enable ATP binding activity. Is expressed in several structures, including extended germ band embryo; foregut primordium; hindgut anlage; presumptive embryonic/larval system; and trunk ectoderm. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
96B2-96B4; 3-86 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24881466..24894605, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20707188..20720327, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Selective maintenance of Drosophila tandemly arranged duplicated genes during evolution. Quijano C, et al. Genome Biol, 2008. PMID 19087263, Free PMC Article
  2. Isolation of microRNA targets by miRNP immunopurification. Easow G, et al. RNA, 2007 Aug. PMID 17592038, Free PMC Article
  3. Characterization of a novel pesticide transporter and P-glycoprotein orthologues in Drosophila melanogaster. Denecke S, et al. Proc Biol Sci, 2022 May 25. PMID 35582794, Free PMC Article
  4. TransportDB: a comprehensive database resource for cytoplasmic membrane transport systems and outer membrane channels. Ren Q, et al. Nucleic Acids Res, 2007 Jan. PMID 17135193, Free PMC Article
  5. ATP-Binding Cassette (ABC) Transporter Genes Involved in Pyrethroid Resistance in the Malaria Vector Anopheles sinensis: Genome-Wide Identification, Characteristics, Phylogenetics, and Expression Profile. He Q, et al. Int J Mol Sci, 2019 Mar 20. PMID 30897799, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG31121-PA
CG31121-PB
NP_733058.1
NP_733059.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    24881466..24894605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_170179.2 → NP_733058.1  uncharacterized protein Dmel_CG31121, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733058.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI14, Q8SXK9
    Related
    FBpp0084098
    Conserved Domains (3) summary
    TIGR01166
    Location:319 → 491
    cbiO; cobalt transport protein ATP-binding subunit
    pfam01061
    Location:621 → 809
    ABC2_membrane; ABC-2 type transporter
    cl21455
    Location:319 → 518
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_170180.2 → NP_733059.1  uncharacterized protein Dmel_CG31121, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733059.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0KI14, Q8SXK9
    Related
    FBpp0084099
    Conserved Domains (3) summary
    TIGR01166
    Location:319 → 491
    cbiO; cobalt transport protein ATP-binding subunit
    pfam01061
    Location:621 → 809
    ABC2_membrane; ABC-2 type transporter
    cl21455
    Location:319 → 518
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0KI14 Q0KI14
Q8SXK9 Q8SXK9
Q9VC17 Q9VC17

Gene LinkOut

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