elavl2 ELAV like neuron-specific RNA binding protein 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: elavl2provided by ZNC
Official Full Name: ELAV like neuron-specific RNA binding protein 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040704-9
See related: Ensembl:ENSDARG00000040732 AllianceGenome:ZFIN:ZDB-GENE-040704-9
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:91918
Summary: Enables mRNA 3'-UTR binding activity. Predicted to be part of ribonucleoprotein complex. Is expressed in central nervous system; head; ovary; and primordial germ cell. Orthologous to human ELAVL2 (ELAV like RNA binding protein 2). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	22	NC_007133.7 (38252726..38274235, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	22	NC_007133.6 (38299579..38321191, complement)

Chromosome 22 - NC_007133.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that DAZL specifically binds the HuB 3'UTR and protects the message from degradation and/or enhances HuB translation, leading to the germ cell specific expression of HuB protein.
Title: HuB (elavl2) mRNA is restricted to the germ cells by post-transcriptional mechanisms including stabilisation of the message by DAZL.
Data show that hub RNA is a target of global miRNA-mediated repression, while the RNA-binding protein Dead end (Dnd) contributes to maintenance of the expression in the primordial germ cells (PGCs).
Title: Regulation of hub mRNA stability and translation by miR430 and the dead end protein promotes preferential expression in zebrafish primordial germ cells.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ELAV-like protein 2

Names: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002172.2 → NP_001002172.2 ELAV-like protein 2

Status: VALIDATED

Source sequence(s)

BC072716, EB918439

UniProtKB/TrEMBL

A0A2R8S0A2, A0A8M1N038

Related

ENSDARP00000157308.1, ENSDART00000179786.1

Conserved Domains (4) summary

cd12650
Location:67 → 144

RRM1_Hu; RNA recognition motif 1 in the Hu proteins family

cd12775
Location:149 → 238

RRM2_HuB; RNA recognition motif 2 in vertebrate Hu-antigen B (HuB)

TIGR01661
Location:65 → 388

ELAV_HUD_SF; ELAV/HuD family splicing factor

cl17169
Location:303 → 388

RRM_SF; RNA recognition motif (RRM) superfamily