U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

spag6 sperm associated antigen 6 [ Danio rerio (zebrafish) ]

Gene ID: 431757, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
spag6provided by ZNC
Official Full Name
sperm associated antigen 6provided by ZNC
Primary source
ZFIN:ZDB-GENE-040704-53
See related
Ensembl:ENSDARG00000020158 AllianceGenome:ZFIN:ZDB-GENE-040704-53
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:91805
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in epithelial cilium movement involved in extracellular fluid movement and plasma membrane bounded cell projection organization. Predicted to be active in acrosomal vesicle; cytoskeleton; and sperm principal piece. Is expressed in several structures, including Kupffer's vesicle; forerunner cell group; nervous system; pronephric duct; and spinal cord neural tube. Orthologous to human SPAG6 (sperm associated antigen 6). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See spag6 in Genome Data Viewer
Location:
chromosome: 24
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 24 NC_007135.7 (17269872..17276771)
105 previous assembly GRCz10 (GCF_000002035.5) 24 NC_007135.6 (17125453..17132352)

Chromosome 24 - NC_007135.7Genomic Context describing neighboring genes Neighboring gene COMM domain containing 3 Neighboring gene bmi1 polycomb ring finger oncogene 1a Neighboring gene polycystin 1 like 1, transient receptor potential channel interacting Neighboring gene si:dkey-117j14.6 Neighboring gene protein disulfide isomerase family A, member 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Evolutionarily ancient association of the FoxJ1 transcription factor with the motile ciliogenic program. Vij S, et al. PLoS Genet, 2012. PMID 23144623, Free PMC Article
  2. Ccdc103 promotes myeloid cell proliferation and migration independent of motile cilia. Falkenberg LG, et al. Dis Model Mech, 2021 May 1. PMID 34028558, Free PMC Article
  3. Single-Cell RNA Sequencing Reveals Size-Dependent Effects of Polystyrene Microplastics on Immune and Secretory Cell Populations from Zebrafish Intestines. Gu W, et al. Environ Sci Technol, 2020 Mar 17. PMID 32092251
  4. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. Austin-Tse C, et al. Am J Hum Genet, 2013 Oct 3. PMID 24094744, Free PMC Article
  5. Identification and Expression Analysis of the Complete Family of Zebrafish pkd Genes. England SJ, et al. Front Cell Dev Biol, 2017. PMID 28271061, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in animal organ development IEA
Inferred from Electronic Annotation
more info
  
involved_in epithelial cilium movement involved in extracellular fluid movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in filopodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection extension IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in acrosomal vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
sperm-associated antigen 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002210.1 → NP_001002210.1  sperm-associated antigen 6

    See identical proteins and their annotated locations for NP_001002210.1

    Status: PROVISIONAL

    Source sequence(s)
    BC074072
    UniProtKB/TrEMBL
    B2GRM8, Q6GMH8
    Related
    ENSDARP00000023131.7, ENSDART00000017605.8
    Conserved Domains (3) summary
    cd00020
    Location:77 → 195
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00044
    Location:293 → 316
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:120 → 152
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007135.7 Reference GRCz11 Primary Assembly

    Range
    17269872..17276771
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools