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Akap7 A kinase anchor protein 7 [ Mus musculus (house mouse) ]

Gene ID: 432442, updated on 9-Dec-2024

Summary

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Official Symbol
Akap7provided by MGI
Official Full Name
A kinase anchor protein 7provided by MGI
Primary source
MGI:MGI:1859150
See related
Ensembl:ENSMUSG00000039166 AllianceGenome:MGI:1859150
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AKAP15; Akap18; 6430401D08
Summary
Enables protein kinase binding activity. Involved in modulation of chemical synaptic transmission. Located in nucleus. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including brain; cartilage; endocrine gland; genitourinary system; and trachea. Orthologous to human AKAP7 (A-kinase anchoring protein 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in cerebellum adult (RPKM 6.0), CNS E18 (RPKM 4.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Akap7 in Genome Data Viewer
Location:
10 A4; 10 12.26 cM
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (25044988..25175115, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (25169090..25299217, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene actin, gamma, cytoplasmic 1 pseudogene Neighboring gene predicted gene, 36313 Neighboring gene STARR-seq mESC enhancer starr_26094 Neighboring gene STARR-seq mESC enhancer starr_26095 Neighboring gene STARR-seq mESC enhancer starr_26096 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene predicted gene, 25016 Neighboring gene STARR-seq mESC enhancer starr_26098 Neighboring gene predicted gene, 40617 Neighboring gene STARR-seq mESC enhancer starr_26101 Neighboring gene erythrocyte membrane protein band 4.1 like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:25123932-25124041 Neighboring gene small leucine-rich protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Green tea catechins enhance norepinephrine-induced lipolysis via a protein kinase A-dependent pathway in adipocytes. Chen S, et al. Biochem Biophys Res Commun, 2015 May 22. PMID 25849890
  2. A novel leucine zipper targets AKAP15 and cyclic AMP-dependent protein kinase to the C terminus of the skeletal muscle Ca2+ channel and modulates its function. Hulme JT, et al. J Biol Chem, 2002 Feb 8. PMID 11733497
  3. Genetic evidence for a role for protein kinase A in the maintenance of sleep and thalamocortical oscillations. Hellman K, et al. Sleep, 2010 Jan. PMID 20120617, Free PMC Article
  4. Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation. Cheng Q, et al. J Neurosci, 2014 Jan 1. PMID 24381273, Free PMC Article
  5. Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo. Fu Y, et al. J Biol Chem, 2011 Apr 8. PMID 21216955, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Requirement of the Ca(2+) channel beta2 subunit for sympathetic PKA phosphorylation.
    Title: Requirement of the Ca(2+) channel β(2) subunit for sympathetic PKA phosphorylation.
  2. Genetic ablation of AKAP7 specifically from dentate granule cells results in disruption of mossy fiber-CA3 pyramidal neuron long-term potentiation directly initiated by cAMP, and the AKAP7 mutant mice are selectively deficient in pattern separation behaviors. The results suggest that the AKAP7/PKA complex in the mossy fiber projections plays an essential role in synaptic plasticity and contextual memory formation.
    Title: Targeted deletion of AKAP7 in dentate granule cells impairs spatial discrimination.
  3. The results demonstrate that green tea catechins enhance lipolysis in the presence of norepinephrine via a PKA-dependent pathway in 3T3-L1 adipocytes, providing a potential mechanism by which green tea catechins could reduce body fat.
    Title: Green tea catechins enhance norepinephrine-induced lipolysis via a protein kinase A-dependent pathway in adipocytes.
  4. Protein kinase A activation enhances hippocampal mossy fiber glutamatergic transmission.
    Title: Presynaptic α7 nicotinic acetylcholine receptors enhance hippocampal mossy fiber glutamatergic transmission via PKA activation.
  5. AKAP7 is not required for regulation of Ca(2+) handling in mouse cardiomyocytes.
    Title: Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation.
  6. AKAP15 co-immunoprecipitates with CaV1.2 and CaV1.3 channels. AKAP15 has overlapping localization with CaV1.2 and CaV1.3 channels in cell bodies and proximal dendrites and is closely co-localized with CaV1.2 channels in punctate clusters.
    Title: Functional roles of a C-terminal signaling complex of CaV1 channels and A-kinase anchoring protein 15 in brain neurons.
  7. CaV1.2 channels in DCT-/- myocytes fail to respond to activation of adenylyl cyclase by forskolin, and the localized expression of AKAP15 is reduced
    Title: Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.
  8. Alterations in cortical synaptic receptors, impairments in sleep continuity, and alterations in sleep oscillations in R(AB) mice imply that PKA is involved not only in synaptic plasticity and memory storage but also in the regulation of sleep/wake states.
    Title: Genetic evidence for a role for protein kinase A in the maintenance of sleep and thalamocortical oscillations.
  9. AKAP7gamma is the first nuclear AKAP to bind RI and may be responsible for positioning PKA via RI and/or RII to regulate PKA-mediated gene transcription in both somatic cells and oocytes
    Title: AKAP7gamma is a nuclear RI-binding AKAP.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables AMP binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase A regulatory subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A regulatory subunit binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
  
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of membrane repolarization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein kinase A signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein kinase A signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 7
Names
A kinase (PRKA) anchor protein 7
A-kinase anchor protein 18
A-kinase anchor protein 9 kDa
AKAP 9
AKAP-18
protein kinase A anchoring protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347460.2 → NP_001334389.1  A-kinase anchor protein 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153549
    Consensus CDS
    CCDS83688.1
    UniProtKB/Swiss-Prot
    G3X9Q5, O55074
    Related
    ENSMUSP00000097590.3, ENSMUST00000100012.3
    Conserved Domains (1) summary
    pfam10470
    Location:23 → 79
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein

  2. NM_001379238.1 → NP_001366167.1  A-kinase anchor protein 7 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variant 1, encodes isoform 1.
    Source sequence(s)
    AC153549, AC153550
    UniProtKB/Swiss-Prot
    F8VQ58, Q7TN79
    Conserved Domains (2) summary
    pfam10470
    Location:256 → 311
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
    pfam10469
    Location:51 → 249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  3. NM_001379239.1 → NP_001366168.1  A-kinase anchor protein 7 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (3).
    Source sequence(s)
    AC153549, AC153550
    Conserved Domains (1) summary
    pfam10469
    Location:51 → 249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  4. NM_001379240.1 → NP_001366169.1  A-kinase anchor protein 7 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC153550
    UniProtKB/TrEMBL
    Q4KL21
    Related
    ENSMUSP00000093455.5, ENSMUST00000095779.11

  5. NM_018747.5 → NP_061217.3  A-kinase anchor protein 7 isoform 1

    See identical proteins and their annotated locations for NP_061217.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1), as well as variant 3, encodes isoform 1.
    Source sequence(s)
    AC153549, AC153550
    Consensus CDS
    CCDS23753.1
    UniProtKB/Swiss-Prot
    F8VQ58, Q7TN79
    Related
    ENSMUSP00000043624.8, ENSMUST00000041984.14
    Conserved Domains (2) summary
    pfam10470
    Location:256 → 311
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
    pfam10469
    Location:51 → 249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

RNA

  1. NR_166567.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153549, AC153550

  2. NR_166568.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153549, AC153550

  3. NR_166569.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC153549

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    25044988..25175115 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512788.4 → XP_006512851.1  A-kinase anchor protein 7 isoform X2

    See identical proteins and their annotated locations for XP_006512851.1

    Conserved Domains (1) summary
    pfam10469
    Location:51 → 249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  2. XM_030245157.2 → XP_030101017.1  A-kinase anchor protein 7 isoform X3

    UniProtKB/Swiss-Prot
    F8VQ58, Q7TN79
    Conserved Domains (2) summary
    pfam10470
    Location:256 → 311
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein
    pfam10469
    Location:51 → 249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  3. XM_030245156.1 → XP_030101016.1  A-kinase anchor protein 7 isoform X2

    Conserved Domains (1) summary
    pfam10469
    Location:51 → 249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  4. XM_006512790.3 → XP_006512853.1  A-kinase anchor protein 7 isoform X2

    See identical proteins and their annotated locations for XP_006512853.1

    Conserved Domains (1) summary
    pfam10469
    Location:51 → 249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  5. XM_036155887.1 → XP_036011780.1  A-kinase anchor protein 7 isoform X2

    Conserved Domains (1) summary
    pfam10469
    Location:51 → 249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  6. XM_006512789.2 → XP_006512852.1  A-kinase anchor protein 7 isoform X2

    See identical proteins and their annotated locations for XP_006512852.1

    Conserved Domains (1) summary
    pfam10469
    Location:51 → 249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  7. XM_006512791.5 → XP_006512854.1  A-kinase anchor protein 7 isoform X2

    See identical proteins and their annotated locations for XP_006512854.1

    Conserved Domains (1) summary
    pfam10469
    Location:51 → 249
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  8. XM_006512793.5 → XP_006512856.1  A-kinase anchor protein 7 isoform X4

    See identical proteins and their annotated locations for XP_006512856.1

    Conserved Domains (1) summary
    pfam10469
    Location:6 → 164
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  9. XM_006512794.5 → XP_006512857.1  A-kinase anchor protein 7 isoform X4

    See identical proteins and their annotated locations for XP_006512857.1

    Conserved Domains (1) summary
    pfam10469
    Location:6 → 164
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

  10. XM_017314023.3 → XP_017169512.1  A-kinase anchor protein 7 isoform X5

    Conserved Domains (1) summary
    pfam10470
    Location:46 → 102
    AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein

  11. XM_036155886.1 → XP_036011779.1  A-kinase anchor protein 7 isoform X1

    Conserved Domains (1) summary
    pfam10469
    Location:187 → 385
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

RNA

  1. XR_001779549.3 RNA Sequence

  2. XR_003948725.2 RNA Sequence

  3. XR_001779547.3 RNA Sequence

  4. XR_001779546.3 RNA Sequence

  5. XR_380068.5 RNA Sequence

  6. XR_380067.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55074.4 GenPept UniProtKB/Swiss-Prot:O55074
Q7TN79.2 GenPept UniProtKB/Swiss-Prot:Q7TN79

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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Chemical Information
Molecular Biology Databases
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