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Rexo5 RNA exonuclease 5 [ Mus musculus (house mouse) ]

Gene ID: 434234, updated on 9-Dec-2024

Summary

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Official Symbol
Rexo5provided by MGI
Official Full Name
RNA exonuclease 5provided by MGI
Primary source
MGI:MGI:1919402
See related
Ensembl:ENSMUSG00000030924 AllianceGenome:MGI:1919402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610020H08Rik
Summary
Predicted to enable exonuclease activity. Predicted to be involved in rRNA 3'-end processing. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in central nervous system and sensory organ. Orthologous to human REXO5 (RNA exonuclease 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in testis adult (RPKM 4.4), CNS E11.5 (RPKM 2.0) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Rexo5 in Genome Data Viewer
Location:
7 F2; 7 64.21 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (119393331..119488130)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (119794117..119880443)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57786 Neighboring gene acyl-CoA synthetase medium-chain family member 3 Neighboring gene exoribonuclease 2 Neighboring gene STARR-seq mESC enhancer starr_20039 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E3747 Neighboring gene STARR-seq mESC enhancer starr_20040 Neighboring gene LYR motif containing 1 Neighboring gene STARR-seq mESC enhancer starr_20041 Neighboring gene dynein, axonemal, heavy chain 3 Neighboring gene predicted gene, 53369

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the mammalian RNA exonuclease 5/NEF-sp as a testis-specific nuclear 3' → 5' exoribonuclease. Silva S, et al. RNA, 2017 Sep. PMID 28539487, Free PMC Article
  2. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  3. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC59529

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in rRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA exonuclease 5
Names
exonuclease NEF-sp

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004187.1 → NP_001004187.1  RNA exonuclease 5 isoform 1

    See identical proteins and their annotated locations for NP_001004187.1

    Status: VALIDATED

    Source sequence(s)
    BC053445
    Consensus CDS
    CCDS21787.1
    UniProtKB/TrEMBL
    Q7TSF9
    Related
    ENSMUSP00000033218.9, ENSMUST00000033218.15
    Conserved Domains (2) summary
    cl10012
    Location:225 → 317
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:424 → 462
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. NM_001370778.1 → NP_001357707.1  RNA exonuclease 5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC122423, AC164158
    UniProtKB/TrEMBL
    D3YW29
    Related
    ENSMUSP00000102130.2, ENSMUST00000106520.9
    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:490 → 560
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. NM_028129.2 → NP_082405.1  RNA exonuclease 5 isoform 2

    See identical proteins and their annotated locations for NP_082405.1

    Status: VALIDATED

    Source sequence(s)
    AC122423, AC164158
    Consensus CDS
    CCDS21788.1
    UniProtKB/TrEMBL
    D3Z3J7
    Related
    ENSMUSP00000081694.3, ENSMUST00000084644.3
    Conserved Domains (2) summary
    cd06145
    Location:33 → 181
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:298 → 368
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    119393331..119488130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241845.4 → XP_011240147.1  RNA exonuclease 5 isoform X1

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:490 → 560
    RRM_SF; RNA recognition motif (RRM) superfamily

  2. XM_006507994.5 → XP_006508057.1  RNA exonuclease 5 isoform X5

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:490 → 560
    RRM_SF; RNA recognition motif (RRM) superfamily

  3. XM_036153220.1 → XP_036009113.1  RNA exonuclease 5 isoform X4

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:555 → 625
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. XM_006507991.5 → XP_006508054.1  RNA exonuclease 5 isoform X2

    See identical proteins and their annotated locations for XP_006508054.1

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:490 → 560
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. XM_030242744.2 → XP_030098604.1  RNA exonuclease 5 isoform X2

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:490 → 560
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_006507990.5 → XP_006508053.1  RNA exonuclease 5 isoform X2

    See identical proteins and their annotated locations for XP_006508053.1

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:490 → 560
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_030242746.2 → XP_030098606.1  RNA exonuclease 5 isoform X6

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:490 → 560
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. XM_006507992.5 → XP_006508055.1  RNA exonuclease 5 isoform X3

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:490 → 560
    RRM_SF; RNA recognition motif (RRM) superfamily

  9. XM_006508000.5 → XP_006508063.1  RNA exonuclease 5 isoform X15

    See identical proteins and their annotated locations for XP_006508063.1

    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:490 → 528
    RRM_SF; RNA recognition motif (RRM) superfamily

  10. XM_006507998.5 → XP_006508061.1  RNA exonuclease 5 isoform X12

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:490 → 560
    RRM_SF; RNA recognition motif (RRM) superfamily

  11. XM_036153228.1 → XP_036009121.1  RNA exonuclease 5 isoform X13

    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:555 → 598
    RRM_SF; RNA recognition motif (RRM) superfamily

  12. XM_006507999.5 → XP_006508062.1  RNA exonuclease 5 isoform X15

    See identical proteins and their annotated locations for XP_006508062.1

    Conserved Domains (2) summary
    cd06145
    Location:225 → 373
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:490 → 528
    RRM_SF; RNA recognition motif (RRM) superfamily

  13. XM_036153221.1 → XP_036009114.1  RNA exonuclease 5 isoform X7

    UniProtKB/TrEMBL
    A0A1Z1GHX5
    Conserved Domains (2) summary
    cl10012
    Location:225 → 317
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily
    cl17169
    Location:424 → 494
    RRM_SF; RNA recognition motif (RRM) superfamily

  14. XM_036153227.1 → XP_036009120.1  RNA exonuclease 5 isoform X11

    Conserved Domains (2) summary
    cd06145
    Location:33 → 181
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:298 → 368
    RRM_SF; RNA recognition motif (RRM) superfamily

  15. XM_036153229.1 → XP_036009122.1  RNA exonuclease 5 isoform X14

    Conserved Domains (2) summary
    cd06145
    Location:145 → 293
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:410 → 480
    RRM_SF; RNA recognition motif (RRM) superfamily

  16. XM_036153226.1 → XP_036009119.1  RNA exonuclease 5 isoform X11

    Conserved Domains (2) summary
    cd06145
    Location:33 → 181
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:298 → 368
    RRM_SF; RNA recognition motif (RRM) superfamily

  17. XM_036153224.1 → XP_036009117.1  RNA exonuclease 5 isoform X10

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:126 → 274
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:391 → 461
    RRM_SF; RNA recognition motif (RRM) superfamily

  18. XM_036153223.1 → XP_036009116.1  RNA exonuclease 5 isoform X9

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:143 → 291
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:408 → 478
    RRM_SF; RNA recognition motif (RRM) superfamily

  19. XM_036153225.1 → XP_036009118.1  RNA exonuclease 5 isoform X11

    Conserved Domains (2) summary
    cd06145
    Location:33 → 181
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:298 → 368
    RRM_SF; RNA recognition motif (RRM) superfamily

  20. XM_036153222.1 → XP_036009115.1  RNA exonuclease 5 isoform X8

    UniProtKB/TrEMBL
    D3YW29
    Conserved Domains (2) summary
    cd06145
    Location:145 → 293
    REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    cl17169
    Location:410 → 480
    RRM_SF; RNA recognition motif (RRM) superfamily

RNA

  1. XR_869733.4 RNA Sequence

  2. XR_378253.5 RNA Sequence

  3. XR_378258.5 RNA Sequence

    Related
    ENSMUST00000133758.9

  4. XR_004934130.1 RNA Sequence

  5. XR_004934132.1 RNA Sequence

  6. XR_004934131.1 RNA Sequence

  7. XR_004934133.1 RNA Sequence

  8. XR_004934134.1 RNA Sequence

  9. XR_004934135.1 RNA Sequence

  10. XR_004934136.1 RNA Sequence

  11. XR_004934137.1 RNA Sequence

  12. XR_004934138.1 RNA Sequence

Nucleotide Protein Strain
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