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Gnpnat Glucosamine-phosphate N-acetyltransferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43504, updated on 4-Jan-2025

Summary

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Official Symbol
Gnpnatprovided by FlyBase
Official Full Name
Glucosamine-phosphate N-acetyltransferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0039690
Locus tag
Dmel_CG1969
See related
AllianceGenome:FB:FBgn0039690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1969; Dmel\CG1969; GNPNAT
Summary
Predicted to enable glucosamine 6-phosphate N-acetyltransferase activity. Predicted to be involved in UDP-N-acetylglucosamine biosynthetic process. Predicted to be located in cytoplasm. Is expressed in several structures, including adult head; dorsal epidermis primordium; embryonic proventriculus; embryonic proventriculus intermediate layer; and epithelium. Orthologous to human GNPNAT1 (glucosamine-phosphate N-acetyltransferase 1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See Gnpnat in Genome Data Viewer
Location:
99B9-99B9; 3-99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (29738275..29741952)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25563997..25567674)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Kuzbanian-like Neighboring gene uncharacterized protein Neighboring gene Complex I intermediate-associated protein, 30 kDa Neighboring gene WD repeat domain 24 Neighboring gene antisense RNA:CR46109 Neighboring gene Integrator 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mosquito glucosamine-6-phosphate N-acetyltransferase: cDNA, gene structure and enzyme kinetics. Kato N, et al. Insect Biochem Mol Biol, 2005 Jun. PMID 15857769
  2. Sugar-responsive inhibition of Myc-dependent ribosome biogenesis by Clockwork orange. van den Berg L, et al. Cell Rep, 2023 Jul 25. PMID 37405919
  3. Genome-wide studies reveal novel and distinct biological pathways regulated by SIN3 isoforms. Saha N, et al. BMC Genomics, 2016 Feb 13. PMID 26872827, Free PMC Article
  4. Isolation of microRNA targets by miRNP immunopurification. Easow G, et al. RNA, 2007 Aug. PMID 17592038, Free PMC Article
  5. RACK1 modulates polyglutamine-induced neurodegeneration by promoting ERK degradation in Drosophila. Xie J, et al. PLoS Genet, 2021 May. PMID 33983927, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables glucosamine 6-phosphate N-acetyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glucosamine 6-phosphate N-acetyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
Glucosamine-phosphate N-acetyltransferase
Names
CG1969-PA
CG1969-PB
CG1969-PD
CG1969-PE
CG1969-PF
CG1969-PG
CG1969-PH
Gnpnat-PA
Gnpnat-PB
Gnpnat-PD
Gnpnat-PE
Gnpnat-PF
Gnpnat-PG
Gnpnat-PH
glucosamine-phosphate N-acetyltransferase
NP_001247360.1
NP_001247361.1
NP_001263079.1
NP_001263080.1
NP_001263081.1
NP_651719.1
NP_733301.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    29738275..29741952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276150.1 → NP_001263079.1  Glucosamine-phosphate N-acetyltransferase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263079.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP97, Q8IMK5
    Conserved Domains (1) summary
    cl17182
    Location:39 → 170
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  2. NM_170422.3 → NP_733301.1  Glucosamine-phosphate N-acetyltransferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733301.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP97, Q8IMK5
    Related
    FBpp0084840
    Conserved Domains (1) summary
    cl17182
    Location:39 → 170
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  3. NM_001276152.1 → NP_001263081.1  Glucosamine-phosphate N-acetyltransferase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263081.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KI57, C6TP97
    Conserved Domains (1) summary
    cl17182
    Location:39 → 170
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  4. NM_001260431.2 → NP_001247360.1  Glucosamine-phosphate N-acetyltransferase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247360.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP97, C6TP98
    Conserved Domains (1) summary
    cl17182
    Location:39 → 170
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  5. NM_143462.4 → NP_651719.1  Glucosamine-phosphate N-acetyltransferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651719.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VAI0
    UniProtKB/TrEMBL
    C6TP97
    Related
    FBpp0084841
    Conserved Domains (1) summary
    cl17182
    Location:43 → 174
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  6. NM_001276151.1 → NP_001263080.1  Glucosamine-phosphate N-acetyltransferase, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263080.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6TP97, Q8IMK5
    Conserved Domains (1) summary
    cl17182
    Location:39 → 170
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate

  7. NM_001260432.2 → NP_001247361.1  Glucosamine-phosphate N-acetyltransferase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001247361.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K7R2, C6TP97
    Conserved Domains (1) summary
    cl17182
    Location:43 → 174
    NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K7R2 A0A0B4K7R2
A0A0B4KI57 A0A0B4KI57
C6TP98 C6TP98
Q8IMK5 Q8IMK5
Q9VAI0.1 Q9VAI0

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