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MPP2 MAGUK p55 scaffold protein 2 [ Homo sapiens (human) ]

Gene ID: 4355, updated on 10-Dec-2024

Summary

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Official Symbol
MPP2provided by HGNC
Official Full Name
MAGUK p55 scaffold protein 2provided by HGNC
Primary source
HGNC:HGNC:7220
See related
Ensembl:ENSG00000108852 MIM:600723; AllianceGenome:HGNC:7220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DLG2
Summary
Palmitoylated membrane protein 2 is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. Palmitoylated membrane protein 2 contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 9.3), testis (RPKM 5.8) and 12 other tissues See more
Orthologs
mouse all
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Genomic context

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See MPP2 in Genome Data Viewer
Location:
17q21.31
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (43875360..43909711, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (44727944..44762256, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (41952728..41987079, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984979 Neighboring gene uncharacterized LOC107985077 Neighboring gene CD300 molecule like family member g Neighboring gene ReSE screen-validated silencer GRCh37_chr17:41943686-41943858 Neighboring gene Sharpr-MPRA regulatory region 5434 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41959115-41959616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41959617-41960116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8570 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12249 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41991041-41991541 Neighboring gene uncharacterized LOC105371787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41994398-41995219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41995220-41996040 Neighboring gene uncharacterized LOC107985086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:41997678-41998178 Neighboring gene family with sequence similarity 215 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A. Mazoyer S, et al. Genomics, 1995 Jul 1. PMID 7590743
  2. A de novo missense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Harada disease as shown by trio-based whole-exome sequencing. Liu X, et al. Cell Mol Immunol, 2023 Nov. PMID 37828081, Free PMC Article
  3. Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21. Smith SA, et al. Genomics, 1996 Jan 15. PMID 8824795
  4. The PDZ protein MPP2 interacts with c-Src in epithelial cells. Baumgartner M, et al. Exp Cell Res, 2009 Oct 15. PMID 19665017
  5. The Kv1-associated molecules TAG-1 and Caspr2 are selectively targeted to the axon initial segment in hippocampal neurons. Pinatel D, et al. J Cell Sci, 2017 Jul 1. PMID 28533267

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A de novo missense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Harada disease as shown by trio-based whole-exome sequencing.
    Title: A de novo missense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Harada disease as shown by trio-based whole-exome sequencing.
  2. MPP2 interacts with c-Src in cells to control c-Src activity and morphological function.
    Title: The PDZ protein MPP2 interacts with c-Src in epithelial cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Heritability and genetic association analysis of cognition in the Diabetes Heart Study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2, MPP2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp686J2189, DKFZp761D0712, DKFZp686A06252

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in excitatory postsynaptic potential ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cell-cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic shaft ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
MAGUK p55 subfamily member 2
Names
discs large, homolog 2
membrane palmitoylated protein 2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278370.2 → NP_001265299.1  MAGUK p55 subfamily member 2 isoform 1

    See identical proteins and their annotated locations for NP_001265299.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC007993, AK295858, AL136554, DC321822
    Consensus CDS
    CCDS62210.1
    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
    UniProtKB/TrEMBL
    A0A0C4DH75
    Related
    ENSP00000428182.1, ENST00000518766.5
    Conserved Domains (6) summary
    smart00569
    Location:58 → 111
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:274 → 332
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:404 → 585
    GuKc; Guanylate kinase homologues
    cd00992
    Location:183 → 261
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:394 → 584
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:113 → 164
    L27; L27 domain

  2. NM_001278371.2 → NP_001265300.1  MAGUK p55 subfamily member 2 isoform 2

    See identical proteins and their annotated locations for NP_001265300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2, 5, and 7 encode the same protein.
    Source sequence(s)
    AC007993, AK295858, AL136554, DC321822, DC333563
    Consensus CDS
    CCDS62207.1
    UniProtKB/TrEMBL
    B4DRL7, B4DZ84
    Related
    ENSP00000480071.1, ENST00000622681.4
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:218 → 276
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:348 → 529
    GuKc; Guanylate kinase homologues
    cd00992
    Location:127 → 205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:57 → 108
    L27; L27 domain

  3. NM_001278372.2 → NP_001265301.1  MAGUK p55 subfamily member 2 isoform 4

    See identical proteins and their annotated locations for NP_001265301.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an alternate coding exon and represents use of an alternate promoter, compared to variant 1. It encodes isoform 4 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC007993, AK299286, AL136554, X82895
    Consensus CDS
    CCDS62209.1
    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
    UniProtKB/TrEMBL
    D3DX49
    Related
    ENSP00000428286.1, ENST00000461854.5
    Conserved Domains (6) summary
    smart00569
    Location:13 → 90
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:253 → 311
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:383 → 564
    GuKc; Guanylate kinase homologues
    cd00992
    Location:162 → 240
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:373 → 563
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:92 → 143
    L27; L27 domain

  4. NM_001278373.2 → NP_001265302.1  MAGUK p55 subfamily member 2 isoform 2

    See identical proteins and their annotated locations for NP_001265302.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon and represents use of an alternate promoter, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2, 5, and 7 encode the same protein.
    Source sequence(s)
    AC007993, AK299286, AL136554
    Consensus CDS
    CCDS62207.1
    UniProtKB/TrEMBL
    B4DRL7, B4DZ84
    Related
    ENSP00000430540.1, ENST00000523501.5
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:218 → 276
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:348 → 529
    GuKc; Guanylate kinase homologues
    cd00992
    Location:127 → 205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:57 → 108
    L27; L27 domain

  5. NM_001278374.2 → NP_001265303.1  MAGUK p55 subfamily member 2 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an in-frame coding exon and represents use of an alternate promoter, compared to variant 1. It encodes isoform 6 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC007993, AK294564, AL136554
    Consensus CDS
    CCDS62206.1
    UniProtKB/TrEMBL
    B4DS08
    Related
    ENSP00000428136.1, ENST00000520305.5
    Conserved Domains (4) summary
    cd12037
    Location:90 → 148
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:220 → 401
    GuKc; Guanylate kinase homologues
    cd00992
    Location:1 → 77
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:210 → 400
    Guanylate_kin; Guanylate kinase

  6. NM_001278375.2 → NP_001265304.1  MAGUK p55 subfamily member 2 isoform 2

    See identical proteins and their annotated locations for NP_001265304.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. It encodes isoform 2 which has a shorter N-terminus compared to isoform 1. Variants 2, 5, and 7 encode the same protein.
    Source sequence(s)
    AC007993, AK302793, AL136554
    Consensus CDS
    CCDS62207.1
    UniProtKB/TrEMBL
    B4DRL7, B4DZ84
    Related
    ENSP00000438012.1, ENST00000536246.5
    Conserved Domains (5) summary
    smart00569
    Location:2 → 55
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:218 → 276
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:348 → 529
    GuKc; Guanylate kinase homologues
    cd00992
    Location:127 → 205
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:57 → 108
    L27; L27 domain

  7. NM_001278376.3 → NP_001265305.2  MAGUK p55 subfamily member 2 isoform 8

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. It encodes isoform 8 which has a distinct N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AC007993, AK299321, AL136554, DC347918
    Consensus CDS
    CCDS62208.1
    UniProtKB/TrEMBL
    A0A0A0MRU0, B4DRL7
    Related
    ENSP00000366389.3, ENST00000377184.7
    Conserved Domains (5) summary
    smart00569
    Location:30 → 83
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:246 → 304
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:376 → 557
    GuKc; Guanylate kinase homologues
    cd00992
    Location:155 → 233
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:85 → 136
    L27; L27 domain

  8. NM_001278381.2 → NP_001265310.1  MAGUK p55 subfamily member 2 isoform 3

    See identical proteins and their annotated locations for NP_001265310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 3 and 9 encode isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC007993, AK299286, AL136554, DC399913
    Consensus CDS
    CCDS11471.1
    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
    UniProtKB/TrEMBL
    D3DX48
    Related
    ENSP00000478528.1, ENST00000612133.4
    Conserved Domains (5) summary
    smart00569
    Location:13 → 66
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:229 → 287
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:359 → 540
    GuKc; Guanylate kinase homologues
    cd00992
    Location:138 → 216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:68 → 119
    L27; L27 domain

  9. NM_005374.5 → NP_005365.4  MAGUK p55 subfamily member 2 isoform 3

    See identical proteins and their annotated locations for NP_005365.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Variants 3 and 9 encode isoform 3 which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC007993, AK223560, AK299286, AL136554
    Consensus CDS
    CCDS11471.1
    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
    UniProtKB/TrEMBL
    D3DX48
    Related
    ENSP00000269095.4, ENST00000269095.9
    Conserved Domains (5) summary
    smart00569
    Location:13 → 66
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:229 → 287
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:359 → 540
    GuKc; Guanylate kinase homologues
    cd00992
    Location:138 → 216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:68 → 119
    L27; L27 domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    43875360..43909711 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450762.2 → XP_024306530.1  MAGUK p55 subfamily member 2 isoform X2

    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
    UniProtKB/TrEMBL
    D3DX48
    Conserved Domains (5) summary
    smart00569
    Location:13 → 66
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:229 → 287
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:359 → 540
    GuKc; Guanylate kinase homologues
    cd00992
    Location:138 → 216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:68 → 119
    L27; L27 domain

  2. XM_011524827.3 → XP_011523129.2  MAGUK p55 subfamily member 2 isoform X5

    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2

  3. XM_024450760.2 → XP_024306528.1  MAGUK p55 subfamily member 2 isoform X1

    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
    Conserved Domains (5) summary
    smart00569
    Location:67 → 120
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:283 → 341
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:413 → 594
    GuKc; Guanylate kinase homologues
    cd00992
    Location:192 → 270
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:122 → 173
    L27; L27 domain

  4. XM_024450763.2 → XP_024306531.1  MAGUK p55 subfamily member 2 isoform X2

    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
    UniProtKB/TrEMBL
    D3DX48
    Conserved Domains (5) summary
    smart00569
    Location:13 → 66
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12037
    Location:229 → 287
    SH3_MPP2; Src Homology 3 domain of Membrane Protein, Palmitoylated 2 (or MAGUK p55 subfamily member 2)
    smart00072
    Location:359 → 540
    GuKc; Guanylate kinase homologues
    cd00992
    Location:138 → 216
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02828
    Location:68 → 119
    L27; L27 domain

  5. XM_047436096.1 → XP_047292052.1  MAGUK p55 subfamily member 2 isoform X4

  6. XM_047436095.1 → XP_047292051.1  MAGUK p55 subfamily member 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    44727944..44762256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054316178.1 → XP_054172153.1  MAGUK p55 subfamily member 2 isoform X2

    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
    UniProtKB/TrEMBL
    D3DX48

  2. XM_054316180.1 → XP_054172155.1  MAGUK p55 subfamily member 2 isoform X2

    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
    UniProtKB/TrEMBL
    D3DX48

  3. XM_054316183.1 → XP_054172158.1  MAGUK p55 subfamily member 2 isoform X5

    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2

  4. XM_054316177.1 → XP_054172152.1  MAGUK p55 subfamily member 2 isoform X1

    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2

  5. XM_054316179.1 → XP_054172154.1  MAGUK p55 subfamily member 2 isoform X2

    UniProtKB/Swiss-Prot
    B4DGE9, B4DRJ0, B7Z3G8, E7EV80, E7EV91, E7EX01, Q14168, Q53ES9, Q5CZB9, Q9BQJ2
    UniProtKB/TrEMBL
    D3DX48

  6. XM_054316182.1 → XP_054172157.1  MAGUK p55 subfamily member 2 isoform X4

  7. XM_054316181.1 → XP_054172156.1  MAGUK p55 subfamily member 2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14168.3 GenPept UniProtKB/Swiss-Prot:Q14168

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