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gbp1 guanylate binding protein 1 [ Danio rerio (zebrafish) ]

Gene ID: 436615, updated on 4-Jan-2025

Summary

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Official Symbol
gbp1provided by ZNC
Official Full Name
guanylate binding protein 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-32
See related
Ensembl:ENSDARG00000038668 AllianceGenome:ZFIN:ZDB-GENE-040718-32
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92185; wu:fd36d06
Summary
Predicted to enable GTP binding activity and GTPase activity. Acts upstream of or within thyroid gland development. Is expressed in thyroid follicle. Orthologous to several human genes including GBP1 (guanylate binding protein 1); GBP2 (guanylate binding protein 2); and GBP3 (guanylate binding protein 3). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
all
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Genomic context

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See gbp1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (42020915..42035314, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (42171497..42185901, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene helicase with zinc finger 2b Neighboring gene guanylate binding protein 2 Neighboring gene centrosome and spindle pole associated protein 1b Neighboring gene valosin containing protein (p97)/p47 complex interacting protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Upregulation of GBP1 in thyroid primordium is required for developmental thyroid morphogenesis. Yang RM, et al. Genet Med, 2021 Oct. PMID 34194003, Free PMC Article
  2. Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein. Jin T, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Aug. PMID 23908027, Free PMC Article
  3. Analysis of interferon gamma protein expression in zebrafish (Danio rerio). Yoon S, et al. Fish Shellfish Immunol, 2016 Oct. PMID 27539703
  4. SARS-CoV-2 viral protein ORF3A injures renal tubules by interacting with TRIM59 to induce STAT3 activation. Cai H, et al. Mol Ther, 2023 Mar 1. PMID 36523164, Free PMC Article
  5. Pericentromeric hypomethylation elicits an interferon response in an animal model of ICF syndrome. Rajshekar S, et al. Elife, 2018 Nov 28. PMID 30484769, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A GBP1 protein was identified contains an N-terminal GTPase domain and a helical domain.
    Title: Structure of the caspase-recruitment domain from a zebrafish guanylate-binding protein.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within thyroid gland development IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
guanylate-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002343.1 → NP_001002343.1  guanylate-binding protein 1

    See identical proteins and their annotated locations for NP_001002343.1

    Status: PROVISIONAL

    Source sequence(s)
    BC075920
    UniProtKB/TrEMBL
    A0A8M2BJ59, Q6DHP7
    Related
    ENSDARP00000056459.5, ENSDART00000056460.7
    Conserved Domains (2) summary
    pfam02841
    Location:283 → 579
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:18 → 281
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    42020915..42035314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005171375.5 → XP_005171432.1  guanylate-binding protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005171432.1

    UniProtKB/TrEMBL
    A0A8M2BJ59, Q6DHP7
    Conserved Domains (2) summary
    pfam02841
    Location:283 → 579
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21455
    Location:18 → 281
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version

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